GNE

Gene Symbol	GNE
Entrez Gene	10020
Alt Symbol	DMRV, GLCNE, IBM2, NM, Uae1
Species	Human
Gene Type	protein-coding
Description	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Other Description	N-acylmannosamine kinase|UDP-GlcNAc-2-epimerase/ManAc kinase|UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase|UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase|bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Swissprots	B2R6E1 B7Z372 H0YFA7 F5H499 A6PZH2 D3DRP7 Q0VA94 A6PZH3 B7Z428 A7UNU7 Q9Y223
Accessions	AAG31661 EAW58307 EAW58308 EAW58309 Q9Y223 AF051852 AAD32251 AF155663 AAD38197 AJ238764 CAB42607 AK295562 BAH12108 AK296687 BAH12414 AK299488 BAH13048 AK312539 BAG35438 AL701451 AM697708 CAM91424 AM697709 CAM91425 AY531126 AAS59257 AY531127 AAS59258 AY531128 AAS59259 BC121179 AAI21180 BF197948 BM996750 BM999446 BP201585 BQ217959 CA503236 DC416534 DC418354 EU093084 ABU55403 XM_005251334 XP_005251391 NM_001128227 NP_001121699 NM_001190383 NP_001177312 NM_001190384 NP_001177313 NM_001190388 NP_001177317 NM_005476 NP_005467
Function	Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. {ECO:0000250, ECO:0000269|PubMed:10334995}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas. Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon. {ECO:0000269|PubMed:10330343, ECO:0000269|PubMed:10431835, ECO:0000269|PubMed:17597614}.
Top Pathways	Amino sugar and nucleotide sugar metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GLCNE full length protein - ab160765 from Abcam Category Protein Source Wheat germ Species Human

Human GLCNE protein fragment - ab160766 from Abcam Category Protein Source Wheat germ Species Human

GLCNE / GNE Antibody Blocking Peptide - LS-E1547 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GLCNE / GNE Antibody Blocking Peptide - LS-E7809 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

N-Acetylmannosamine Kinase/GNE Partial Recombinant Protein - H00010020-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

N-Acetylmannosamine Kinase/GNE Recombinant Protein - H00010020-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

GNE-Antibody-N-term-Blocking-peptide - BP12285a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GNE-Antibody-C-term-Blocking-peptide - BP5318b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human N-Acetylmannosamine Kinase/GNE, CF - 8268-GK-050 from R&D Systems Category Protein Source E. coli-derived, Thr406-Arg720, with an N-terminal Met and 6-His tag

GNE / GLCNE - H00010020-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

GNE / GLCNE - H00010020-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

GNE / GLCNE - H00010020-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GNE / GLCNE - H00010020-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GNE fusion protein - Ag18702 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GNE fusion protein - Ag18689 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant LXRα protein - 31122 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant LXRβ protein - 31123 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant c-Myc protein - 31117 from ActiveMotif Category Protein Prices $445.00 Sizes 5 µg Source E. coli Species Human

Recombinant PPARα protein - 31125 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant PPARβ(δ) protein - 31126 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant PPARγ protein - 31127 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant Rad51 protein - 31129 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant RXR-α protein - 31133 from ActiveMotif Category Protein Prices $395.00 Sizes 10 µg Source E. coli Species Human

Recombinant RXR-β protein - 31134 from ActiveMotif Category Protein Prices $395.00 Sizes 5 µg Source E. coli Species Human

Recombinant RXR-LBD protein - 31135 from ActiveMotif Category Protein Prices $395.00 Sizes 10 µg Source E. coli Species Human

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