GNE

Gene Symbol GNE
Entrez Gene 10020
Alt Symbol DMRV, GLCNE, IBM2, NM, Uae1
Species Human
Gene Type protein-coding
Description glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Other Description N-acylmannosamine kinase|UDP-GlcNAc-2-epimerase/ManAc kinase|UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase|UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase|bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Swissprots B2R6E1 B7Z372 H0YFA7 F5H499 A6PZH2 D3DRP7 Q0VA94 A6PZH3 B7Z428 A7UNU7 Q9Y223
Accessions AAG31661 EAW58307 EAW58308 EAW58309 Q9Y223 AF051852 AAD32251 AF155663 AAD38197 AJ238764 CAB42607 AK295562 BAH12108 AK296687 BAH12414 AK299488 BAH13048 AK312539 BAG35438 AL701451 AM697708 CAM91424 AM697709 CAM91425 AY531126 AAS59257 AY531127 AAS59258 AY531128 AAS59259 BC121179 AAI21180 BF197948 BM996750 BM999446 BP201585 BQ217959 CA503236 DC416534 DC418354 EU093084 ABU55403 XM_005251334 XP_005251391 NM_001128227 NP_001121699 NM_001190383 NP_001177312 NM_001190384 NP_001177313 NM_001190388 NP_001177317 NM_005476 NP_005467
Function Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. {ECO:0000250, ECO:0000269|PubMed:10334995}.
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas. Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon. {ECO:0000269|PubMed:10330343, ECO:0000269|PubMed:10431835, ECO:0000269|PubMed:17597614}.
Top Pathways Amino sugar and nucleotide sugar metabolism

GLCNE (H-10) - sc-376057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GLCNE (H-10): sc-376057. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

GLCNE (D-8) - sc-374512 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GLCNE (D-8): sc-374512. Western blot analysis of GLCNE expression in non-transfected: sc-117752 (A) and mouse GLCNE transfected: sc-125387 (B) 293T whole cell lysates.

GLCNE (H-300) - sc-134809 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GLCNE (H-300): sc-134809. Western blot analysis of GLCNE expression in mouse brain tissue extract.

GLCNE (G-12) - sc-271481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GLCNE (G-12): sc-271481. Western blot analysis of GLCNE expression in non-transfected: sc-117752 (A) and mouse GLCNE transfected: sc-125387 (B) 293T whole cell lysates.

GLCNE (T-19) - sc-49951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GLCNE (T-19): sc-49951. Western blot analysis of GLCNE expression in non-transfected: sc-117752 (A) and mouse GLCNE transfected: sc-125387 (B) 293T whole cell lysates.

GLCNE (N-20) - sc-49950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GLCNE (N-20): sc-49950. Western blot analysis of GLCNE expression in non-transfected: sc-117752 (A) and mouse GLCNE transfected: sc-125387 (B) 293T whole cell lysates.

Anti-GLCNE antibody - ab199416 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GLCNE antibody (ab199416) at 1/500 dilution + Human liver tissue lysate at 35 µgSecondarygoat anti-rabbit IgG H&L (HRP) at 1/5000 dilution

Anti-GLCNE antibody - ab172537 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GLCNE antibody (ab172537) at 1 µg/mlLane 1 : GLCNE transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG at 1/7500 dilution

Anti-GLCNE antibody - ab103843 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GLCNE antibody (ab103843) at 1/100 dilution + Mouse kidney tissue lysates at 35 µg

Anti-GLCNE antibody [EPR15058] - ab184963 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15058
All lanes : Anti-GLCNE antibody [EPR15058] (ab184963) at 1/10000 dilutionLane 1 : Human fetal liver lysateLane 2 : Human placenta lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-GLCNE antibody [EPR15059] - C-terminal - ab189927 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15059
All lanes : Anti-GLCNE antibody [EPR15059] - C-terminal (ab189927) at 1/1000 dilutionLane 1 : Human fetal liverLane 2 : Human fetal kidneyLane 3 : Human fetal brainLysates/proteins at 20 µg per lane.SecondaryAnti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Anti-GLCNE antibody - N-terminal - ab170550 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human liver tissue labeling GLCNE with ab170550 at 1/10 followed by peroxidase conjugation of the secondary antibody and DAB staining

Anti-GLCNE / GNE Antibody (aa169-197, PE) - LS-C235822 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa169-197, Biotin) - LS-C235820 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa580-607, Azide-free, HRP) - LS-C249096 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody - LS-C310511 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa169-197, Azide-free, HRP) - LS-C249097 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa168-197) - LS-C321688 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa592-641) - LS-C291439 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa588-618) - LS-C321687 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa580-607) - LS-C166560 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GNE Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The GNE antibody detected GNE protein (arrow).

Anti-GLCNE / GNE Antibody (aa169-197) - LS-C166561 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GNE Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-GLCNE / GNE Antibody (aa580-607, AP) - LS-C235813 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa580-607, Biotin) - LS-C235814 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GLCNE / GNE Antibody (aa580-607, APC) - LS-C235815 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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