| Gene Symbol | PNP |
|---|---|
| Entrez Gene | 4860 |
| Alt Symbol | NP, PRO1837, PUNP |
| Species | Human |
| Gene Type | protein-coding |
| Description | purine nucleoside phosphorylase |
| Other Description | HEL-S-156an|epididymis secretory sperm binding protein Li 156an|inosine phosphorylase|inosine-guanosine phosphorylase|purine-nucleoside:orthophosphate ribosyltransferase |
| Swissprots | Q15160 B2R8S5 P00491 D3DS00 Q5PZ03 |
| Accessions | AAA36460 AAV68044 EAW66458 EAW66459 P00491 AK098544 BAC05327 AK126154 AK307340 AK307364 AK313490 BAG36272 BC104206 AAI04207 BC104207 AAI04208 BC106074 AAI06075 BM193354 BU622706 CR407607 CAG28535 EU794649 ACJ13703 X00737 CAA25320 NM_000270 NP_000261 |
| Function | The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. {ECO:0000269|PubMed:2104852}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:22509282}. |
| Tissue Specificity | Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. {ECO:0000269|PubMed:22509282}. |
| Top Pathways | Purine metabolism, Nicotinate and nicotinamide metabolism, Pyrimidine metabolism |