HDAC7

Gene Symbol HDAC7
Entrez Gene 51564
Alt Symbol HD7A, HDAC7A
Species Human
Gene Type protein-coding
Description histone deacetylase 7
Other Description HD7|histone deacetylase 7A
Swissprots Q9NYK9 B3KY08 Q9UFU7 Q9NW41 Q7Z4K2 Q8WUI4 Q9BR73 Q6P1W9 B4DWI0 B4E0Q5 Q6W9G7 Q7Z5I1 Q9NWA9 Q9H7L0 Q96K01
Accessions EAW57952 EAW57953 EAW57954 EAW57955 EAW57956 EAW57957 EAW57958 Q8WUI4 AF239243 AAF63491 AK001032 BAA91474 AK001190 BAA91545 AK024387 AK024469 BAB15759 AK026767 BAB15546 AK027781 BAB55363 AK122588 BAC56929 AK128383 BAG54670 AK225910 AK299292 BAG61307 AK301545 BAG63042 AK303481 BAG64517 AK309547 AL117455 CAB55935 AY302468 AAQ18232 AY321367 AAP84704 BC006453 AAH06453 BC020505 AAH20505 BC064840 AAH64840 BM144303 BT009771 AAP88773 DC376749 XM_005268968 XP_005269025 XM_006719454 XP_006719517 XM_011538478 XP_011536780 XM_011538479 XP_011536781 XM_011538480 XP_011536782 XM_011538481 XP_011536783 XM_011538482 XP_011536784 XM_011538483 XP_011536785 NM_001098416 NP_001091886 NM_001308090 NP_001295019 NM_015401 NP_056216 NM_016596
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565}.
Subcellular Location Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Top Pathways Viral carcinogenesis, Alcoholism

Histone Deacetylase 7 (HDAC7) Antibody - 2882 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of various cell lysates, using Histone Deacetylase 7 (HDAC7) Antibody.

HDAC4/5/7 (H-273) - sc-11421 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HDAC4/5/7 (H-273): sc-11421. Western blot analysis of human recombinant HDAC7 fusion protein.

HDAC7 (A-7) - sc-74563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC7 (A-7): sc-74563. Western blot analysis of HDAC7 expression in non-transfected: sc-110760 (A) and human HDAC7 transfected: sc-112934 (B) 293 whole cell lysates.

HDAC7 (L-19) - sc-11493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HDAC7 (L-19): sc-11493. Western blot analysis of HDAC7 expression in NIH/3T3 nuclear extract.

HDAC7 (C-18) - sc-11491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HDAC7 (C-18): sc-11491. Western blot analysis of HDAC7 expression in NIH/3T3 whole cell lysate.

HDAC7 (N-18) - sc-11489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HDAC7 (N-18): sc-11489. Western blot analysis of HDAC7 expression in NIH/3T3 whole cell lysate.

Anti-HDAC7 (phospho S155) antibody - ab111390 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab111390 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab111390, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-HDAC7 antibody - ab12174 from Abcam

Prices $387.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HDAC7 antibody - ab1441 from Abcam

Prices $373.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC7 antibody - ab53101 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab53096, at a 1/50 dilution, staining HDAC7 in paraffin embedded human lung carcinoma tissue sections by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.

Anti-HDAC7 antibody - ab12175 from Abcam

Prices $372.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HDAC7 antibody - ab23657 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC7 antibody (ab23657) at 1 µg/mlLane 1 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell LysateLane 2 : Heart (Human) Tissue Lysate - fetal normal tissueLane 3 : Heart (Human) Tissue Lysate - adult normal tissueLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutionPerformed under reducing conditions.

Anti-HDAC7 antibody - ab196951 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC7 antibody (ab196951) at 1/500 dilutionLane 1 : JK cell extract with synthesized peptideLane 2 : JK cell extract

Anti-HDAC7 antibody - ab68349 from Abcam

Host Mouse
Clonality Monoclonal
Anti-HDAC7 antibody (ab68349) at 1/500 dilution + K562 cell lysate at 25 µg/mlSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-HDAC7 antibody [EPR10922] - ab166911 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10922
All lanes : Anti-HDAC7 antibody [EPR10922] (ab166911) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human fetal brain tissue lysateLane 3 : A549 cell lysateLane 4 : K562 cell lysateLysates/proteins at 10 µg per lane.

Anti-HDAC7 antibody [HDAC7-97] - ChIP Grade - ab50212 from Abcam

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone HDAC7-97

HDAC7 Antibody - NBP1-44092 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HDAC7 Antibody [NBP1-44092] - Lane 1: mouse brain homogenate. Lane 2: mouse brain homogenate blocked with peptide. Load: 4 ug per lane. Primary antibody: HDAC7 antibody at 1ug/mL for overnight at 4C. Secondary antibody: HRP rabbit secondary antibody at 1:40,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4C. Predicted/Observed size: 103kDa/ 103, 70, and 40kDa for HDAC7. Other band(s): HDAC7 isoforms 70 and 40kDa.

HDAC7 Antibody - NBP2-16795 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HDAC7 Antibody [NBP2-16795] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE gel, diluted at 1:1000.

HDAC7 Antibody (2B11-1C1) - H00051564-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B11-1C1
Western Blot: HDAC7 Antibody (2B11-1C1) [H00051564-M01] - Western blot analysis of HDAC7A over-expressed 293 cell line, cotransfected with HDAC7A Validated Chimera RNAi or non-transfected control. Blot probed with H00051564-M01. GAPDH (36.1 kDa) used as loading control.

HDAC7 Antibody - NBP2-16794 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HDAC7 Antibody [NBP2-16794] - Sample (20 ug of whole cell lysate) A: 293T transfected HDAC7-FLAG NBP2-16794 diluted at 1:2000.

HDAC7 Antibody - H00051564-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: HDAC7 Antibody [H00051564-B01] - analysis of HDAC7A expression in transfected 293T cell line by HDAC7A MaxPab polyclonal antibody (B01). Lane1: HDAC7A transfected lysate (29.60 KDa). Lane2: Non-transfected lysate.

HDAC7 Antibody - H00051564-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

HDAC7 Antibody - H00051564-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

HDAC7(Ser486) Polyclonal Antibody - bs-10330R from Bioss

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-HDAC7(Ser486) Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-10330R-A350 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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