| Gene Symbol |
HDAC7
|
| Entrez Gene |
51564
|
| Alt Symbol |
HD7A, HDAC7A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone deacetylase 7
|
| Other Description |
HD7|histone deacetylase 7A
|
| Swissprots |
Q9NYK9 B3KY08 Q9UFU7 Q9NW41 Q7Z4K2 Q8WUI4 Q9BR73 Q6P1W9 B4DWI0 B4E0Q5 Q6W9G7 Q7Z5I1 Q9NWA9 Q9H7L0 Q96K01
|
| Accessions |
EAW57952 EAW57953 EAW57954 EAW57955 EAW57956 EAW57957 EAW57958 Q8WUI4 AF239243 AAF63491 AK001032 BAA91474 AK001190 BAA91545 AK024387 AK024469 BAB15759 AK026767 BAB15546 AK027781 BAB55363 AK122588 BAC56929 AK128383 BAG54670 AK225910 AK299292 BAG61307 AK301545 BAG63042 AK303481 BAG64517 AK309547 AL117455 CAB55935 AY302468 AAQ18232 AY321367 AAP84704 BC006453 AAH06453 BC020505 AAH20505 BC064840 AAH64840 BM144303 BT009771 AAP88773 DC376749 XM_005268968 XP_005269025 XM_006719454 XP_006719517 XM_011538478 XP_011536780 XM_011538479 XP_011536781 XM_011538480 XP_011536782 XM_011538481 XP_011536783 XM_011538482 XP_011536784 XM_011538483 XP_011536785 NM_001098416 NP_001091886 NM_001308090 NP_001295019 NM_015401 NP_056216 NM_016596
|
| Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
|
| Top Pathways |
Viral carcinogenesis, Alcoholism
|
![Western Blot: HDAC7 Overexpression Lysate (Adult Normal) [NBP2-07000] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HDAC7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8609_HDAC7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07000-img0001.jpg)