HDAC7

Gene Symbol	HDAC7
Entrez Gene	51564
Alt Symbol	HD7A, HDAC7A
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 7
Other Description	HD7|histone deacetylase 7A
Swissprots	Q9NYK9 B3KY08 Q9UFU7 Q9NW41 Q7Z4K2 Q8WUI4 Q9BR73 Q6P1W9 B4DWI0 B4E0Q5 Q6W9G7 Q7Z5I1 Q9NWA9 Q9H7L0 Q96K01
Accessions	EAW57952 EAW57953 EAW57954 EAW57955 EAW57956 EAW57957 EAW57958 Q8WUI4 AF239243 AAF63491 AK001032 BAA91474 AK001190 BAA91545 AK024387 AK024469 BAB15759 AK026767 BAB15546 AK027781 BAB55363 AK122588 BAC56929 AK128383 BAG54670 AK225910 AK299292 BAG61307 AK301545 BAG63042 AK303481 BAG64517 AK309547 AL117455 CAB55935 AY302468 AAQ18232 AY321367 AAP84704 BC006453 AAH06453 BC020505 AAH20505 BC064840 AAH64840 BM144303 BT009771 AAP88773 DC376749 XM_005268968 XP_005269025 XM_006719454 XP_006719517 XM_011538478 XP_011536780 XM_011538479 XP_011536781 XM_011538480 XP_011536782 XM_011538481 XP_011536783 XM_011538482 XP_011536784 XM_011538483 XP_011536785 NM_001098416 NP_001091886 NM_001308090 NP_001295019 NM_015401 NP_056216 NM_016596
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565}.
Subcellular Location	Nucleus. Cytoplasm. Note=In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Top Pathways	Viral carcinogenesis, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HDAC7 protein fragment - ab101660 from Abcam Category Protein Source Baculovirus Species Human

HDAC7 peptide - ab41709 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human HDAC7 peptide - ab27456 from Abcam Category Peptide

HDAC7-Antibody-C-term-Blocking-Peptide - BP1107a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HDAC7-Antibody-C-term-Blocking-peptide - BP13647b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human HDAC7 protein - orb245689 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human HDAC7 protein - orb245690 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Histone Deacetylase 7 Blocking Peptide - abx063868 from Abbexa Category Peptide Species Human, Mouse, Rat

HDAC7 - H00051564-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HDAC7 - H00051564-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HDAC7 control peptide - AP00276CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

HDAC7 fusion protein - ag8277 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

HDAC7 fusion protein - ag1101 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Distone Deacetylase 7, GST-tagged - HDAC7-1594H from Creative Biomart Category Protein Species Human

Recombinant Human Histone Deacetylase 7, GST-tagged - HDAC7-398H from Creative Biomart Category Protein Source HDAC7 was cloned from human heart cDNA and expressed in insect cells using a baculoviral expression system.

Recombinant Human HDAC7 - HDAC7-29191TH from Creative Biomart Category Protein Source Baculovirus

Recombinant Human HDAC7, His-tagged - HDAC7-13710H from Creative Biomart Category Protein Source E.coli Species Human

HDAC7, active recombinant protein - 14-832 from EMD Millipore Category Protein Source Expressed by baculovirus in Sf9 insect cells. Species Human

Histone Deacetylase 7 Blocking Peptide - CBP2674 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

HDAC 7 (G932) Peptide - BS1166P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant human Histone deacetylase 7 - CSB-EP178994h(C) CSB-BP178994h(C) CSB-MP178994h(C) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Histone deacetylase 7 - CSB-EP178994h(N) CSB-BP178994h(N) CSB-MP178994h(N) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Histone deacetylase 7(HDAC7),partial - CSB-RP178994h(C) from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Histone deacetylase 7(HDAC7),partial - CSB-RP178994h(N) from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Histone deacetylase 7(HDAC7) ,partial - CSB-YP010243HU CSB-EP010243HU CSB-BP010243HU CSB-MP010243HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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