Gene Symbol | SLC12A3 |
---|---|
Entrez Gene | 6559 |
Alt Symbol | NCC, NCCT, TSC |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 12 (sodium/chloride transporter), member 3 |
Other Description | Na-Cl cotransporter|Na-Cl symporter|NaCl electroneutral thiazide-sensitive cotransporter|solute carrier family 12 member 3|thiazide-sensitive Na-Cl cotransporter|thiazide-sensitive sodium-chloride cotransporter |
Swissprots | P55017 A8MSJ2 C9JNN9 |
Accessions | AAK38112 CCQ42979 EAW82888 EAW82889 EAW82890 EAW82891 P55017 AK223133 AK315298 BC111850 AAI11851 BF510426 U44128 AAC50355 X91220 CAA62613 XM_005256119 XP_005256176 NM_000339 NP_000330 NM_001126107 NP_001119579 NM_001126108 NP_001119580 |
Function | Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. {ECO:0000269|PubMed:8528245}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Predominant in kidney. |
NCCT CRISPR/Cas9 KO Plasmid (h) - sc-402965 from Santa Cruz Biotechnology
|
||||||||
NCCT HDR Plasmid (h) - sc-402965-HDR from Santa Cruz Biotechnology
|
||||||||
NCCT Double Nickase Plasmid (h) - sc-402965-NIC from Santa Cruz Biotechnology
|
||||||||
NCCT Double Nickase Plasmid (h2) - sc-402965-NIC-2 from Santa Cruz Biotechnology
|
||||||||
NCCT CRISPR Activation Plasmid (h) - sc-402965-ACT from Santa Cruz Biotechnology
|
||||||||
NCCT CRISPR Activation Plasmid (h2) - sc-402965-ACT-2 from Santa Cruz Biotechnology
|
||||||||
NCCT Lentiviral Activation Particles (h) - sc-402965-LAC from Santa Cruz Biotechnology
|
||||||||
NCCT Lentiviral Activation Particles (h2) - sc-402965-LAC-2 from Santa Cruz Biotechnology
|
||||||||
NCCT siRNA (h) - sc-42515 from Santa Cruz Biotechnology
|
||||||||
NCCT shRNA Plasmid (h) - sc-42515-SH from Santa Cruz Biotechnology
|
||||||||
NCCT shRNA (h) Lentiviral Particles - sc-42515-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU009551 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19405 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19405 from Sigma-Aldrich
|
||||||||
SLC12A3 siRNA (Human) - CRH4449 from Cohesion Biosciences
|
||||||||
SLC12A3 RNAi - H00006559-R01 from Novus Biologicals
|
||||||||
SLC12A3 - MBS8214029 from MyBioSource
|
||||||||
shRNA set against Human Slc12a3 (NM_000339.2) - SHH408324 from Creative biogene
|
||||||||
SLC12A3 shRNA Plasmid (Human) - CHH4449 from Cohesion Biosciences
|