| Gene Symbol |
CHAF1A
|
| Entrez Gene |
10036
|
| Alt Symbol |
CAF-1, CAF1, CAF1B, CAF1P150, P150
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromatin assembly factor 1, subunit A (p150)
|
| Other Description |
CAF-1 subunit A|CAF-I 150 kDa subunit|CAF-I p150|CTB-50L17.7|chromatin assembly factor 1 subunit A|chromatin assembly factor I (150 kDa)|chromatin assembly factor I p150 subunit|hp150
|
| Swissprots |
Q7Z7K3 Q6NXG5 Q13111 Q9UJY8
|
| Accessions |
AAF04291 EAW69224 EAW69225 EAW69226 Q13111 AA576757 BC005813 BC011560 BC041606 BC052620 AAH52620 BC067093 AAH67093 BE796132 BG775588 BM826511 BQ889365 H98924 HG510268 U20979 AAA76736 XM_011527605 XP_011525907 XM_011527606 XP_011525908 XM_011527607 XP_011525909 XR_936135 NM_005483 NP_005474
|
| Function |
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). {ECO:0000250, ECO:0000269|PubMed:15327775}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10052459}. Note=DNA replication foci.
|
![Western Blot: CHAF1A Overexpression Lysate (Adult Normal) [NBL1-09139] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHAF1A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3170_CHAF1A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09139-img0002.jpg)