Gene Symbol | CHAF1A |
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Entrez Gene | 10036 |
Alt Symbol | CAF-1, CAF1, CAF1B, CAF1P150, P150 |
Species | Human |
Gene Type | protein-coding |
Description | chromatin assembly factor 1, subunit A (p150) |
Other Description | CAF-1 subunit A|CAF-I 150 kDa subunit|CAF-I p150|CTB-50L17.7|chromatin assembly factor 1 subunit A|chromatin assembly factor I (150 kDa)|chromatin assembly factor I p150 subunit|hp150 |
Swissprots | Q7Z7K3 Q6NXG5 Q13111 Q9UJY8 |
Accessions | AAF04291 EAW69224 EAW69225 EAW69226 Q13111 AA576757 BC005813 BC011560 BC041606 BC052620 AAH52620 BC067093 AAH67093 BE796132 BG775588 BM826511 BQ889365 H98924 HG510268 U20979 AAA76736 XM_011527605 XP_011525907 XM_011527606 XP_011525908 XM_011527607 XP_011525909 XR_936135 NM_005483 NP_005474 |
Function | Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). {ECO:0000250, ECO:0000269|PubMed:15327775}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10052459}. Note=DNA replication foci. |
CHAF1A (D77D5) XP ® Rabbit mAb - 5480 from Cell Signaling Technology
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CAF-1 p150 (K-16) - sc-10203 from Santa Cruz Biotechnology
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CAF-1 p150 (D-1) - sc-133105 from Santa Cruz Biotechnology
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CAF-1 p150 (C-21) - sc-10205 from Santa Cruz Biotechnology
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CAF-1 p150 (26) - sc-136500 from Santa Cruz Biotechnology
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CAF-1 p150 (C-3) - sc-137141 from Santa Cruz Biotechnology
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CAF-1 p150 (H-300) - sc-10772 from Santa Cruz Biotechnology
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CAF-1 p150 (p150-1) - sc-56642 from Santa Cruz Biotechnology
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CAF-1 p150 (p150-48) - sc-32742 from Santa Cruz Biotechnology
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CAF-1 p150 (SS 1 1-13) - sc-56643 from Santa Cruz Biotechnology
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CAF-1 p150 (C-5) - sc-133068 from Santa Cruz Biotechnology
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CAF-1 p150 (D-16) - sc-10206 from Santa Cruz Biotechnology
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Anti-p150 CAF1 antibody - ab196768 from Abcam
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Anti-p150 CAF1 antibody - ab101286 from Abcam
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Anti-p150 CAF1 antibody [1SS-48] - ab30327 from Abcam
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Anti-p150 CAF1 antibody [EPR5576(2)] - ab126625 from Abcam
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Anti-CHAF1A / CAF1 Antibody - LS-C125365 from LifeSpan Bioscience
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Anti-CHAF1A / CAF-1 Antibody (aa21-120, clone 10B2214, Azide-free) - LS-C183517 from LifeSpan Bioscience
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Anti-CHAF1A / CAF1 Antibody (clone 2168C3a) - LS-C184718 from LifeSpan Bioscience
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Anti-CHAF1A / CAF1 Antibody (aa21-120) - LS-C306928 from LifeSpan Bioscience
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Anti-CHAF1A / CAF1 Antibody (aa878-938) - LS-C288277 from LifeSpan Bioscience
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Anti-CHAF1A / CAF1 Antibody (clone p150-48) - LS-C179637 from LifeSpan Bioscience
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Anti-CHAF1A / CAF1 Antibody - LS-C332007 from LifeSpan Bioscience
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Anti-CHAF1A / CAF1 Antibody (aa500-550) - LS-C286204 from LifeSpan Bioscience
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Anti-CHAF1A / CAF1 Antibody (aa100-150) - LS-C288275 from LifeSpan Bioscience
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