| Gene Symbol | ADRB1 |
|---|---|
| Entrez Gene | 153 |
| Alt Symbol | ADRB1R, B1AR, BETA1AR, RHR |
| Species | Human |
| Gene Type | protein-coding |
| Description | adrenoceptor beta 1 |
| Other Description | adrenergic, beta-1-, receptor|beta-1 adrenergic receptor|beta-1 adrenoceptor|beta-1 adrenoreceptor |
| Swissprots | P08588 Q9UKG7 B0LPE2 Q9UKG8 Q5T5Y4 |
| Accessions | AAD53696 AAD53697 AAG40474 AAS66983 ABY87521 CAN37601 CBX55891 EAW49485 P08588 AF272890 BC169224 AAI69224 BC169225 AAI69225 BC169226 AAI69226 J03019 AAA51667 NM_000684 NP_000675 |
| Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. {ECO:0000269|PubMed:12391161}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}. |
| Top Pathways | cAMP signaling pathway, cGMP-PKG signaling pathway, Adrenergic signaling in cardiomyocytes, Salivary secretion, Dilated cardiomyopathy |