Gene Symbol | ADRB1 |
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Entrez Gene | 153 |
Alt Symbol | ADRB1R, B1AR, BETA1AR, RHR |
Species | Human |
Gene Type | protein-coding |
Description | adrenoceptor beta 1 |
Other Description | adrenergic, beta-1-, receptor|beta-1 adrenergic receptor|beta-1 adrenoceptor|beta-1 adrenoreceptor |
Swissprots | P08588 Q9UKG7 B0LPE2 Q9UKG8 Q5T5Y4 |
Accessions | AAD53696 AAD53697 AAG40474 AAS66983 ABY87521 CAN37601 CBX55891 EAW49485 P08588 AF272890 BC169224 AAI69224 BC169225 AAI69225 BC169226 AAI69226 J03019 AAA51667 NM_000684 NP_000675 |
Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. {ECO:0000269|PubMed:12391161}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}. |
Top Pathways | cAMP signaling pathway, cGMP-PKG signaling pathway, Adrenergic signaling in cardiomyocytes, Salivary secretion, Dilated cardiomyopathy |
Active human ADRB1 Gly389 + GsaL fusion full length protein - ab90784 from Abcam
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Active human ADRB1 Gly389 + GsaS fusion full length protein - ab90781 from Abcam
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Active human ADRB1 Gly389 full length protein - ab90785 from Abcam
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Human ADRB1 + GsaL fusion full length protein - ab90775 from Abcam
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Human ADRB1 + GsaS fusion full length protein - ab90827 from Abcam
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Mouse beta 1 Adrenergic Receptor peptide - ab97424 from Abcam
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ADRB1 Antibody Blocking Peptide - LS-E13092 from LifeSpan Bioscience
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ADRB1 Antibody Blocking Peptide - LS-E26048 from LifeSpan Bioscience
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beta 1 Adrenergic Receptor blocking peptide - GTX89376-PEP from GeneTex
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Human ADRB1 protein - orb246716 from Biorbyt
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beta 1 Adrenergic Receptor Immunizing peptide - orb17248 from Biorbyt
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ADRB1 Blocking Peptide - 33R-1826 from Fitzgerald
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Beta 1 Adrenergic Receptor Peptide - AC21-0876-P from Abcore
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ADRB1 Peptide - 45-211P from ProSci
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Beta-1 Adrenergic Receptor Peptide - 300119 from ABBIOTEC
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Recombinant Human Adrenergic, Beta-1-, Receptor, Flag-His - ADRB1-1017H from Creative Biomart
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Recombinant Human ADBR1 and GsαS fusion protein, Flag and His-tagged - ADRB1-1035H from Creative Biomart
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Recombinant Adrenergic Receptor Beta 1 (ADRb1) - RPC924Mu01 from Uscn Life Science Inc.
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Recombinant Adrenergic Receptor Beta 1 (ADRb1) - RPC924Mu02 from Uscn Life Science Inc.
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Recombinant Adrenergic Receptor Beta 1 (ADRb1) - RPC924Ra01 from Uscn Life Science Inc.
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AR-β1 (A302) Peptide - BS2210P from Bioworld Technology
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Recombinant Human Beta-1 adrenergic receptor(ADRB1) - CSB-EP001391HU CSB-BP001391HU CSB-MP001391HU from Cusabio
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Recombinant Human Beta-1 adrenergic receptor(ADRB1) - CSB-YP001391HU from Cusabio
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ADRB1, Peptide - MBS425130 from MyBioSource
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Recombinant Human ADRB1 Arg389-GsalphaS - CSI13845 from Cell Science
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