| Gene Symbol |
ADRB1
|
| Entrez Gene |
153
|
| Alt Symbol |
ADRB1R, B1AR, BETA1AR, RHR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adrenoceptor beta 1
|
| Other Description |
adrenergic, beta-1-, receptor|beta-1 adrenergic receptor|beta-1 adrenoceptor|beta-1 adrenoreceptor
|
| Swissprots |
P08588 Q9UKG7 B0LPE2 Q9UKG8 Q5T5Y4
|
| Accessions |
AAD53696 AAD53697 AAG40474 AAS66983 ABY87521 CAN37601 CBX55891 EAW49485 P08588 AF272890 BC169224 AAI69224 BC169225 AAI69225 BC169226 AAI69226 J03019 AAA51667 NM_000684 NP_000675
|
| Function |
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. {ECO:0000269|PubMed:12391161}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. {ECO:0000250}.
|
| Top Pathways |
cAMP signaling pathway, cGMP-PKG signaling pathway, Adrenergic signaling in cardiomyocytes, Salivary secretion, Dilated cardiomyopathy
|