PITRM1

Gene Symbol PITRM1
Entrez Gene 10531
Alt Symbol MP1, PreP
Species Human
Gene Type protein-coding
Description pitrilysin metallopeptidase 1
Other Description PreP peptidasome|metalloprotease 1 (pitrilysin family)|pitrilysin metalloproteinase 1|presequence protease, mitochondrial
Swissprots Q2M2G6 B4E0J8 Q4VBR1 C9JSL2 Q7L5Z7 Q9UPP8 B3KMJ6 O95204 Q9BSI6 Q5JRW7 Q5JRX3 Q9BVJ5 E7ES23
Accessions EAW86490 EAW86491 EAW86492 EAW86493 Q5JRX3 AA132969 AB029027 BAA83056 AF061243 AAC67244 AK001183 BAG50863 AK002061 BAG51008 AK023476 BAG51199 AK225084 AK293788 BAG57201 AK294865 BAG57968 AK299464 BAG61430 AK303406 BAG64460 AK315117 AL117409 BC001150 AAH01150 BC005025 AAH05025 BC045577 BC095422 AAH95422 BC111987 AAI11988 BC113369 AAI13370 BG720390 BI766649 BM737694 BX649017 CB529735 CD692197 CR749279 CAH18134 DA331909 XM_005252345 XP_005252402 XM_006717362 XP_006717425 XM_011519292 XP_011517594 NM_014968 NM_001242307 NP_001229236 NM_001242309 NP_001229238 NM_014889 NP_055704
Function ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. {ECO:0000269|PubMed:16849325}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:16849325}.
Tissue Specificity Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta. {ECO:0000269|PubMed:10360838}.

PITRM1 CRISPR/Cas9 KO Plasmid (h) - sc-411482 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 HDR Plasmid (h) - sc-411482-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 Double Nickase Plasmid (h) - sc-411482-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 Double Nickase Plasmid (h2) - sc-411482-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 CRISPR Activation Plasmid (h) - sc-411482-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 CRISPR Activation Plasmid (h2) - sc-411482-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 Lentiviral Activation Particles (h) - sc-411482-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 Lentiviral Activation Particles (h2) - sc-411482-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PITRM1 siRNA (h) - sc-76151 from Santa Cruz Biotechnology

Category siRNA
Species Reactivities Human

PITRM1 shRNA Plasmid (h) - sc-76151-SH from Santa Cruz Biotechnology

Category siRNA
Species Reactivities Human

PITRM1 shRNA (h) Lentiviral Particles - sc-76151-V from Santa Cruz Biotechnology

Category siRNA
Species Reactivities Human

MISSION® esiRNA - EHU011041 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16843 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16843 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02048 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02048

PITRM1 siRNA (Human) - CRH7157 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PITRM1 shRNA Plasmid (Human) - CHH7157 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PITRM1 miRNA 3'UTR clone - MiUTR3H-15724 from Creative biogene

Species Reactivities Human
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