TREX1

Gene Symbol	TREX1
Entrez Gene	11277
Alt Symbol	AGS1, CRV, DRN3, HERNS
Species	Human
Gene Type	protein-coding
Description	three prime repair exonuclease 1
Other Description	3' repair exonuclease 1|3'-5' exonuclease TREX1|DNase III|deoxyribonuclease III|three-prime repair exonuclease 1
Swissprots	Q8TEU2 B2RCN9 Q9NSU2 Q9BPW1 Q9Y4X2
Accessions	AAL82504 CCQ43540 EAW64883 Q9NSU2 AF151105 AAD48774 AJ243797 CAB50866 AK315196 BAG37636 AL137745 BC019863 BC023630 AAH23630 BC160084 AAI60084 BQ933154 BT020052 AAV38855 BT020053 AAV38856 CR457119 CAG33400 DA364183 DA850044 EU832638 ACE87729 EU832715 ACE87047 NM_007248 NP_009179 NM_016381 NP_057465 NM_033629 NP_338599 NM_033627 NM_033628
Function	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:103919
Subcellular Location	Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death. {ECO:0000250}.
Tissue Specificity	Detected in thymus, spleen, liver, brain, heart, small intestine and colon. {ECO:0000269|PubMed:10393201, ECO:0000269|PubMed:11278605}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TREX1 Antibody - 12215 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

ATRIP (H-300) - sc-33790 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

ATRIP (V-20) - sc-33411 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ATRIP (N-19) - sc-33410 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TREX-1 (E-6) - sc-271870 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TREX-1 (L-19) - sc-66291 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TREX-1 (K-15) - sc-66290 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TREX-1 (M-114) - sc-67293 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TREX-1 (S-18) - sc-66294 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TREX-1 (C-14) - sc-66288 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TREX-1 (H-80) - sc-67292 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-TREX1 antibody - ab83890 from Abcam Prices $384.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TREX1 antibody - ab67192 from Abcam Prices $378.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-TREX1 antibody - ab151434 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TREX1 antibody [EPR14985] - ab185228 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14985

Anti-TREX1 Antibody - LS-C335702 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TREX1 Antibody (Internal) - LS-C82903 from LifeSpan Bioscience Prices $345.00, $1,035.00 Sizes 100 µg, 500 µg Host Rabbit Clonality Polyclonal

TREX1 Antibody - NBP2-29617 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

TREX1 Antibody - NBP1-76977 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TREX1 Antibody (41M5F2) - NBP2-22394 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 41M5F2

TREX1 Antibody - H00011277-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TREX1 Antibody - NBP2-20701 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TREX1 Antibody - H00011277-B02P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

TREX1 Antibody - H00011277-B02 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

TREX1 Antibody - H00011277-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

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