TREX1

Gene Symbol	TREX1
Entrez Gene	11277
Alt Symbol	AGS1, CRV, DRN3, HERNS
Species	Human
Gene Type	protein-coding
Description	three prime repair exonuclease 1
Other Description	3' repair exonuclease 1|3'-5' exonuclease TREX1|DNase III|deoxyribonuclease III|three-prime repair exonuclease 1
Swissprots	Q8TEU2 B2RCN9 Q9NSU2 Q9BPW1 Q9Y4X2
Accessions	AAL82504 CCQ43540 EAW64883 Q9NSU2 AF151105 AAD48774 AJ243797 CAB50866 AK315196 BAG37636 AL137745 BC019863 BC023630 AAH23630 BC160084 AAI60084 BQ933154 BT020052 AAV38855 BT020053 AAV38856 CR457119 CAG33400 DA364183 DA850044 EU832638 ACE87729 EU832715 ACE87047 NM_007248 NP_009179 NM_016381 NP_057465 NM_033629 NP_338599 NM_033627 NM_033628
Function	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:103919
Subcellular Location	Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death. {ECO:0000250}.
Tissue Specificity	Detected in thymus, spleen, liver, brain, heart, small intestine and colon. {ECO:0000269|PubMed:10393201, ECO:0000269|PubMed:11278605}.
Top Pathways	Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TREX1 293T Cell Transient Overexpression Lysate(Denatured) - H00011277-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TREX1 293T Cell Transient Overexpression Lysate(Denatured) - H00011277-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TREX1 overexpression lysate - LY402546 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TREX1 293 Cell Lysate - 402229 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

TREX1 Overexpression Lysate (Denatured) - H00011277-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

TREX1 Overexpression Lysate (Denatured) - H00011277-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

TREX1 Overexpression Lysate (Native) - NBL1-17267 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TREX1 Over-expression Lysate Product - GWB-93670A from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

TREX1 Overexpression Lysate (Denatured) - H00011277-T04 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human TREX1 Knockdown Stable Cell Line - CSC-DC016554 from Creative biogene Category Cell Line Species Human

Human TREX1 Knockout Cell Line-HeLa - CSC-RT1457 from Creative biogene Category Cell Line Species Human

TREX1 KO Cell Lysate-HeLa - CLKO-1307 from Creative biogene Category Cell Lysate

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