BST2

Gene Symbol	BST2
Entrez Gene	684
Alt Symbol	CD317, TETHERIN
Species	Human
Gene Type	protein-coding
Description	bone marrow stromal cell antigen 2
Other Description	BST-2|HM1.24 antigen|NPC-A-7|bone marrow stromal antigen 2
Swissprots	Q53G07 Q10589 A8K4Y4
Accessions	EAW84602 EAW84603 Q10589 AI077344 AK223124 BAD96844 AK291099 BAF83788 AK303593 BAG64608 AY320400 AY320402 AAP73804 BC033873 AAH33873 CB047887 D28137 BAA05679 NM_004335 NP_004326
Function	IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (E
Subcellular Location	Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm.
Tissue Specificity	Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level). {ECO:0000269|PubMed:10329429, ECO:0000269|PubMed:16157322}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BST-2 (E-4) - sc-390719 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

BST-2 (K-15) - sc-46811 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

BST-2 (H-135) - sc-99191 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

BST-2 (N-17) - sc-46812 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-BST2 antibody - ab88523 from Abcam Prices $390.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-BST2 antibody - ab14694 from Abcam Prices $372.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 antibody - ab70003 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 antibody - ab135968 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 antibody - ab122941 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BST2 antibody [EPR5648] - ab134061 from Abcam Prices $99.00 Sizes 10 µl Host Rabbit Clonality Monoclonal Clone EPR5648

Anti-BST2 Antibody (aa1-180) - LS-C121438 from LifeSpan Bioscience Prices $445.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-BST2 Antibody - LS-C77307 from LifeSpan Bioscience Prices $575.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (aa1-180) - LS-C127124 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (aa40-180) - LS-C306582 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-BST2 Antibody (aa124-169) - LS-C313689 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (aa73-83) - LS-C112958 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-BST2 Antibody (N-Terminus) - LS-C145354 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (aa80-130) - LS-C148823 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (aa1-180) IHC-plus™ - LS-B8015 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody - LS-C331760 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (aa81-130) - LS-C119784 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (aa65-114) - LS-C200189 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BST2 Antibody (Extracellular Domain, clone EPR5648) - LS-C138652 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5648

BST2 Antibody - NBP2-27154 from Novus Biologicals Prices $99.00, $299.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

BST2 Antibody (2E2) - NBP2-29621 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 2E2

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