BST2

Gene Symbol	BST2
Entrez Gene	684
Alt Symbol	CD317, TETHERIN
Species	Human
Gene Type	protein-coding
Description	bone marrow stromal cell antigen 2
Other Description	BST-2|HM1.24 antigen|NPC-A-7|bone marrow stromal antigen 2
Swissprots	Q53G07 Q10589 A8K4Y4
Accessions	EAW84602 EAW84603 Q10589 AI077344 AK223124 BAD96844 AK291099 BAF83788 AK303593 BAG64608 AY320400 AY320402 AAP73804 BC033873 AAH33873 CB047887 D28137 BAA05679 NM_004335 NP_004326
Function	IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (E
Subcellular Location	Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm.
Tissue Specificity	Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level). {ECO:0000269|PubMed:10329429, ECO:0000269|PubMed:16157322}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BST2 full length protein - ab112254 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human BST2 protein fragment - ab114390 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human BST2 protein fragment - ab109848 from Abcam Category Protein Prices $402.00, $1,210.00 Sizes 50 µg, 250 µg Source E. coli Species Human

BST2 Antibody Blocking Peptide - LS-E22472 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BST2 Antibody Blocking Peptide - LS-E27325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BST2 Recombinant Protein - H00000684-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BST2 Recombinant Protein - H00000684-P03 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human BST2 Protein - H00000684-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human BST2 Protein - NBP1-72363 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E.coli Species Human

BST2 Recombinant Protein - H00000684-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD317 blocking peptide - GTX88171-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human BST2 protein - orb180182 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source Human Cells Species Human

Human CD317 protein - orb138272 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Human Cells Species Human

Human CD317 protein - orb138273 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Human Cells Species Human

BST2 protein (His tag) - 80R-1875 from Fitzgerald Category Protein Prices $395.00 Sizes 50 µg Source E.coli

BST2 Blocking Peptide - abx062306 from Abbexa Category Peptide Species Human, Mouse, Rat

BST2 Peptide - AC21-2147-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD317 / BST2 (50-161, His-tag) - AR39057PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

CD317 / BST2 (50-161, His-tag) - AR39057PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

CD317 / BST2 - H00000684-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD317 / BST2 - H00000684-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD317 / BST2 - H00000684-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD317 / BST2 - H00000684-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CD317 / BST2 - H00000684-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD317 / BST2 - H00000684-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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