BST2

Gene Symbol	BST2
Entrez Gene	684
Alt Symbol	CD317, TETHERIN
Species	Human
Gene Type	protein-coding
Description	bone marrow stromal cell antigen 2
Other Description	BST-2|HM1.24 antigen|NPC-A-7|bone marrow stromal antigen 2
Swissprots	Q53G07 Q10589 A8K4Y4
Accessions	EAW84602 EAW84603 Q10589 AI077344 AK223124 BAD96844 AK291099 BAF83788 AK303593 BAG64608 AY320400 AY320402 AAP73804 BC033873 AAH33873 CB047887 D28137 BAA05679 NM_004335 NP_004326
Function	IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason- Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (E
Subcellular Location	Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane {ECO:0000250}. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm.
Tissue Specificity	Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level). {ECO:0000269|PubMed:10329429, ECO:0000269|PubMed:16157322}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BST2 ELISA Kit (Sandwich ELISA) - LS-F7199 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human BST2 ELISA Kit - abx150844 from Abbexa Category ELISA Kit Sensitivity 0.058 ng/ml Range 0.156 ng/ml - 10 ng/ml

Bone marrow stromal antigen 2 (BST2), Human, ELISA Kit - CSB-EL002837HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Bone marrow stromal antigen 2 (BST2), Human, ELISA Kit - E01B0858 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Bone Marrow Stromal Cell Antigen 2 (BST2), Human, ELISA Kit - SEB777Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.068ng/mL Range 0.156-10ng/mL

BST2 (Human) IP-WB Antibody Pair - H00000684-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BST2 (Human) IP-WB Antibody Pair - H00000684-PW3 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BST2 (Human) Matched Antibody Pair - H00000684-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BST2 (Human) Matched Antibody Pair - H00000684-AP12 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BST2 (Human) Matched Antibody Pair - H00000684-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BST2 (Human) Matched Antibody Pair - H00000684-AP22 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BST2 (Human) Matched Antibody Pair - H00000684-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7205120 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7232009 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7203602 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7232816 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7223607 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7224911 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7251034 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7227766 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7223223 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7219133 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7207125 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone marrow stromal antigen 2 (BST2), ELISA Kit - MBS7216089 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bone Marrow Stromal Cell Antigen 2, ELISA Kit - MBS081665 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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