DNAJB6

Gene Symbol DNAJB6
Entrez Gene 10049
Alt Symbol DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1
Species Human
Gene Type protein-coding
Description DnaJ (Hsp40) homolog, subfamily B, member 6
Other Description DnaJ-like 2 protein|dnaJ homolog subfamily B member 6|heat shock protein J2
Swissprots Q53EN8 E9PCZ2 A8KAG0 Q59EF2 A8K7D8 O95806 A4D232 Q9UIK6 O75190 Q6FIC8 Q75MA2 B4DN73
Accessions AAS07392 AAS07393 AAS07521 EAL23923 EAL23924 EAX04570 EAX04571 O75190 AB014888 BAA32209 AB015798 BAA88769 AB015799 BAA88770 AB209859 BAD93096 AF060703 AAF21257 AF075601 AAD43194 AK055429 AK093837 AK124827 AK223601 BAD97321 AK291953 BAF84642 AK293025 BAF85714 AK297497 BAG59911 AK297796 BAG60135 AK297989 BAG60297 AK301152 BAG62743 AL136707 CAB66642 AL832124 AM392548 CAL37426 AM392741 CAL37619 AM393348 CAL38226 BC000177 AAH00177 BC002446 AAH02446 BC018175 BC043270 AAH43270 BC110289 CR533498 CAG38529 EU075177 ABU54861 XM_005249515 XP_005249572 XM_005249516 XP_005249573 XM_006715823 XP_006715886 XM_011515704 XP_011514006 NM_005494 NP_005485 NM_058246 NP_490647
Function Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}.
Subcellular Location Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Tissue Specificity Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus. {ECO:0000269|PubMed:10319584, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:9915854}.

DnaJ/HSP40 Homolog Subfamily C, Member 12 (DNAJC12) BioAssay™ ELISA Kit (Human) - 024702 from USBiological Life Science

Category ELISA Kit
Sensitivity 0.057ng/ml
Range 0.156-10ng/ml

Dnaj/Hsp40 Homolog Subfamily C, Member 12, DNAJC12, Human, ELISA Kit - YHB1036Hu from ARP American Research Products

Category ELISA Kit

Heat Shock Protein 40 (HSP40), Human, ELISA Kit - SEA872Hu from ARP American Research Products

Category ELISA Kit
Prices $650.00
Sizes 96 t
Sensitivity 0.043ng/mL
Range 0.156-10 ng/mL

DNAJB6 (Human) IP-WB Antibody Pair - H00010049-PW2 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

DNAJB6 (Human) Matched Antibody Pair - H00010049-AP21 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

DnaJ/HSP40 Homolog Subfamily C, Member 12, ELISA Kit - MBS062513 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DnaJ/HSP40 Homolog Subfamily C, Member 12, ELISA Kit - MBS059994 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DnaJ/HSP40 Homolog Subfamily C, Member 12, ELISA Kit - MBS100998 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DnaJ/HSP40 Homolog Subfamily C, Member 12, ELISA Kit - MBS081616 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DnaJ/HSP40 Homolog Subfamily C, Member 12, ELISA Kit - MBS099029 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DnaJ/HSP40 Homolog Subfamily C, Member 12, ELISA Kit - MBS074209 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DnaJ/HSP40 Homolog Subfamily C, Member 12, ELISA Kit - MBS105197 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DnaJ (Hsp40) homolog, subfamily B, member 6, ELISA Kit - MBS9340752 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Heat Shock Protein 40 (HSP40) - SEA872Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.045ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human DnaJ/HSP40 Homolog Subfamily C, Member 12 (DNAJC12) ELISA Kit - EKU03775 from Biomatik

Category ELISA Kit
Prices $735.00, $3,234.00, $5,880.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 0.057 ng/mL
Range 0.156-10 ng/mL

Human HSP-27/HSPB1(Heat Shock Protein 27) ELISA Kit - E-EL-H1861 from Iwai North America Inc.

Category ELISA Kit
Prices $495.00
Sizes 1 kit
Sensitivity 0.1 ng/mLng/mL
Range 0.16~10 ng/mL

Human DnaJ/HSP40 Homolog Subfamily C, Member 13 ELISA Kit - abx258157 from Abbexa

Category ELISA Kit
Range 0.781 ng/ml - 50 ng/ml

Human DnaJ/HSP40 Homolog Subfamily C, Member 13 (DNAJC13) ELISA Kit - EKU09373 from Biomatik

Category ELISA Kit
Prices $809.00, $3,557.00, $6,468.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 0.33 ng/mL
Range 0.781-50 ng/mL

Human DNAJB6 ELISA Kit - E012195 from Biobool

Category ELISA Kit
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