DNAJB6

Gene Symbol	DNAJB6
Entrez Gene	10049
Alt Symbol	DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1
Species	Human
Gene Type	protein-coding
Description	DnaJ (Hsp40) homolog, subfamily B, member 6
Other Description	DnaJ-like 2 protein|dnaJ homolog subfamily B member 6|heat shock protein J2
Swissprots	Q53EN8 E9PCZ2 A8KAG0 Q59EF2 A8K7D8 O95806 A4D232 Q9UIK6 O75190 Q6FIC8 Q75MA2 B4DN73
Accessions	AAS07392 AAS07393 AAS07521 EAL23923 EAL23924 EAX04570 EAX04571 O75190 AB014888 BAA32209 AB015798 BAA88769 AB015799 BAA88770 AB209859 BAD93096 AF060703 AAF21257 AF075601 AAD43194 AK055429 AK093837 AK124827 AK223601 BAD97321 AK291953 BAF84642 AK293025 BAF85714 AK297497 BAG59911 AK297796 BAG60135 AK297989 BAG60297 AK301152 BAG62743 AL136707 CAB66642 AL832124 AM392548 CAL37426 AM392741 CAL37619 AM393348 CAL38226 BC000177 AAH00177 BC002446 AAH02446 BC018175 BC043270 AAH43270 BC110289 CR533498 CAG38529 EU075177 ABU54861 XM_005249515 XP_005249572 XM_005249516 XP_005249573 XM_006715823 XP_006715886 XM_011515704 XP_011514006 NM_005494 NP_005485 NM_058246 NP_490647
Function	Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}.
Subcellular Location	Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Tissue Specificity	Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus. {ECO:0000269|PubMed:10319584, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:9915854}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DnaJ full length protein - ab51305 from Abcam Category Protein Source E. coli Species Human

Human DNAJB6 full length protein - ab105132 from Abcam Category Protein Source E. coli Species Human

DNAJB6 Antibody Blocking Peptide - LS-E1716 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNAJB6 Antibody Blocking Peptide - LS-E18882 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNAJB6 Recombinant Protein - H00010049-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DNAJB6 Partial Recombinant Protein - H00010049-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human DNAJB6 Protein - NBP1-50943 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

DNAJB6-Antibody-Center-Blocking-peptide - BP12493c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DNAJB6 Protein (OPPA02606) - OPPA02606 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

E. coli DnaJ protein - orb81484 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Species Escherichia coli

Human DNAJB6 protein - orb168242 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Source E. coli

Human DnaJ protein - orb81485 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

2810451A06Rik Blocking Peptide - 33R-5495 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNAJB6 Blocking Peptide - 33R-7052 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNAJB6 protein (His tag) - 80R-1618 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

DNAJB6 (1-326, His-tag) - AR09799PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

DNAJB6 (1-326, His-tag) - AR09799PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

DNAJB6 - H00010049-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNAJB6 - H00010049-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DNAJB6 - H00010049-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DNAJB6 - H00010049-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DNAJB6, 1-326aa, Human, His tag, E.coli - 01-P0859 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

DNAJB6 fusion protein - Ag2258 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

DNAJB6 Human - HYPS-045 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 1 µg, 5 µg, 50 µg Source Escherichia Coli. Species Human

Recombinant Human DNAJB6 Protein - BP001979-HSP-038 from Syd Labs Category Protein Prices $160.00, $1,200.00 Sizes 5 µg, 50 µg Source E. coli-derived. Species Human

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