DNAJB6

Gene Symbol	DNAJB6
Entrez Gene	10049
Alt Symbol	DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MRJ, MSJ-1
Species	Human
Gene Type	protein-coding
Description	DnaJ (Hsp40) homolog, subfamily B, member 6
Other Description	DnaJ-like 2 protein|dnaJ homolog subfamily B member 6|heat shock protein J2
Swissprots	Q53EN8 E9PCZ2 A8KAG0 Q59EF2 A8K7D8 O95806 A4D232 Q9UIK6 O75190 Q6FIC8 Q75MA2 B4DN73
Accessions	AAS07392 AAS07393 AAS07521 EAL23923 EAL23924 EAX04570 EAX04571 O75190 AB014888 BAA32209 AB015798 BAA88769 AB015799 BAA88770 AB209859 BAD93096 AF060703 AAF21257 AF075601 AAD43194 AK055429 AK093837 AK124827 AK223601 BAD97321 AK291953 BAF84642 AK293025 BAF85714 AK297497 BAG59911 AK297796 BAG60135 AK297989 BAG60297 AK301152 BAG62743 AL136707 CAB66642 AL832124 AM392548 CAL37426 AM392741 CAL37619 AM393348 CAL38226 BC000177 AAH00177 BC002446 AAH02446 BC018175 BC043270 AAH43270 BC110289 CR533498 CAG38529 EU075177 ABU54861 XM_005249515 XP_005249572 XM_005249516 XP_005249573 XM_006715823 XP_006715886 XM_011515704 XP_011514006 NM_005494 NP_005485 NM_058246 NP_490647
Function	Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. {ECO:0000269|PubMed:10954706, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:20159555, ECO:0000269|PubMed:22366786}.
Subcellular Location	Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Tissue Specificity	Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus. {ECO:0000269|PubMed:10319584, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:9915854}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DnaJB6 (B-5) - sc-365574 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

DnaJB6 (E-17) - sc-104204 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DnaJB6 (F-8) - sc-365573 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

DnaJB6 (S-15) - sc-104207 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DnaJB6 (RQ-6) - sc-100710 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-DNAJB6 antibody - ab169373 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DNAJB6 antibody [EPR17122] - N-terminal - ab198995 from Abcam Prices $347.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR17122

Anti-DNAJB6 Antibody (aa1-116) IHC-plus™ - LS-B10756 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody (aa218-247, Biotin) - LS-C234674 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody (aa218-247, PE) - LS-C234681 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 / DnaJ Antibody (aa1-242, clone 10B2742, Azide-free) - LS-C183566 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 10B2742

Anti-DNAJB6 Antibody (aa218-247, APC) - LS-C234675 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody (aa218-247, AP) - LS-C234676 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody (aa218-247, FITC) - LS-C234677 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody (aa218-247, Azide-free, HRP) - LS-C249850 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody - LS-C310160 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody - LS-C310161 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody - LS-C307278 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DNAJB6 Antibody (clone 2C11-C1) - LS-C307276 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2C11-C1

Anti-DNAJB6 Antibody (aa36-85) - LS-C81727 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody (aa217-247) - LS-C320890 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody - LS-C346206 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DNAJB6 Antibody (clone 1A5) - LS-C139332 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1A5

Anti-DNAJB6 Antibody (aa218-247) - LS-C167465 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DnaJ / HSP40 Antibody (aa1-387, clone 10B2740, Azide-free) - LS-C183564 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 10B2740

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