| Gene Symbol |
CHD4
|
| Entrez Gene |
1108
|
| Alt Symbol |
CHD-4, Mi-2b, Mi2-BETA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromodomain helicase DNA binding protein 4
|
| Other Description |
ATP-dependent helicase CHD4|Mi-2 autoantigen 218 kDa protein|chromodomain-helicase-DNA-binding protein 4
|
| Swissprots |
Q8IXZ5 Q14839
|
| Accessions |
EAW88777 EAW88778 EAW88779 Q14839 AA099889 AK128741 BAG54725 BC014964 AAH14964 BC025962 AAH25962 BC038596 AAH38596 BP234473 CR936680 EU446505 ABZ92034 X86691 CAA60384 XM_005253668 XP_005253725 XM_006718958 XP_006719021 XM_006718959 XP_006719022 XM_006718960 XP_006719023 XM_006718961 XP_006719024 XM_006718962 XP_006719025 NM_001273 NP_001264 NM_001297553 NP_001284482
|
| Function |
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17626165}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase. {ECO:0000250|UniProtKB:Q6PDQ2}.
|
| Top Pathways |
Viral carcinogenesis
|
![Western Blot: CHD4 Overexpression Lysate (Native) [L034T6] - Lane 1: CHD4 transfected lysate (220 KDa). Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/43_CHD4-Overexpression-Lysate-(Native)-Western-Blot-L034T6-img0001.jpg)