Gene Symbol | CHD4 |
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Entrez Gene | 1108 |
Alt Symbol | CHD-4, Mi-2b, Mi2-BETA |
Species | Human |
Gene Type | protein-coding |
Description | chromodomain helicase DNA binding protein 4 |
Other Description | ATP-dependent helicase CHD4|Mi-2 autoantigen 218 kDa protein|chromodomain-helicase-DNA-binding protein 4 |
Swissprots | Q8IXZ5 Q14839 |
Accessions | EAW88777 EAW88778 EAW88779 Q14839 AA099889 AK128741 BAG54725 BC014964 AAH14964 BC025962 AAH25962 BC038596 AAH38596 BP234473 CR936680 EU446505 ABZ92034 X86691 CAA60384 XM_005253668 XP_005253725 XM_006718958 XP_006719021 XM_006718959 XP_006719022 XM_006718960 XP_006719023 XM_006718961 XP_006719024 XM_006718962 XP_006719025 NM_001273 NP_001264 NM_001297553 NP_001284482 |
Function | Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17626165}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase. {ECO:0000250|UniProtKB:Q6PDQ2}. |
Top Pathways | Viral carcinogenesis |
Mi2-b CRISPR/Cas9 KO Plasmid (h) - sc-402185 from Santa Cruz Biotechnology
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Mi2-b HDR Plasmid (h) - sc-402185-HDR from Santa Cruz Biotechnology
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Mi2-b Double Nickase Plasmid (h) - sc-402185-NIC from Santa Cruz Biotechnology
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Mi2-b Double Nickase Plasmid (h2) - sc-402185-NIC-2 from Santa Cruz Biotechnology
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Mi2-b CRISPR Activation Plasmid (h) - sc-402185-ACT from Santa Cruz Biotechnology
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Mi2-b CRISPR Activation Plasmid (h2) - sc-402185-ACT-2 from Santa Cruz Biotechnology
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Mi2-b Lentiviral Activation Particles (h) - sc-402185-LAC from Santa Cruz Biotechnology
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Mi2-b Lentiviral Activation Particles (h2) - sc-402185-LAC-2 from Santa Cruz Biotechnology
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Mi2-β siRNA (h) - sc-37953 from Santa Cruz Biotechnology
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Mi2-β shRNA Plasmid (h) - sc-37953-SH from Santa Cruz Biotechnology
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Mi2-β shRNA (h) Lentiviral Particles - sc-37953-V from Santa Cruz Biotechnology
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CHD4 RNAi - H00001108-R02 from Novus Biologicals
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MISSION® esiRNA - EHU062901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6044 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6044 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04433 from Sigma-Aldrich
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CHD4 siRNA (Human) - CRH0790 from Cohesion Biosciences
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CHD4 - MBS8209228 from MyBioSource
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shRNA set against Human CHD4 (NM_001273.2) - SHH262865 from Creative biogene
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shRNA set against Human CHD4(NM_001273.2) - SHG174043 from Creative biogene
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Human CHD4 siRNA - orb261292 from Biorbyt
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CHD4 shRNA Plasmid (Human) - CHH0790 from Cohesion Biosciences
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CHD4 miRNA 3'UTR clone - MiUTR1H-02108 from Creative biogene
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