Clu
| Gene Symbol | Clu |
|---|---|
| Entrez Gene | 24854 |
| Alt Symbol | APOJ, CLI, DAG, RATTRPM2B, SGP-2, SGP2, SP-40, SP40, TRPM-2, TRPM2B, Trpm2, Trpmb |
| Species | Rat |
| Gene Type | protein-coding |
| Description | clusterin |
| Other Description | dimeric acid glycoprotein|sulfated glycoprotein 2|testosterone repressed prostate message 2|testosterone-repressed prostate message|testostrone-repressed prostate message 2 |
| Swissprots | P05371 |
| Accessions | AAA18641 AAA42299 EDL85369 EDL85370 EDL85371 EDL85372 P05371 AF314657 AAG31162 BC061534 AAH61534 FQ209467 FQ209498 FQ209623 FQ211071 FQ213433 FQ214098 FQ218237 FQ218812 FQ219030 M16975 AAA41273 M64723 AAA42298 X13231 CAA31618 XM_006252094 XP_006252156 NM_053021 NP_444180 |
| Function | Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promote |
| Subcellular Location | Secreted {ECO:0000269|PubMed:3415696, ECO:0000269|PubMed:3651384}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250}. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis (By similarity). {ECO:0000250}. |
| Tissue Specificity | Detected in Sertoli cells (at protein level). Detected in cultured Sertoli cells, testis, epididymis, liver and brain. {ECO:0000269|PubMed:3651384}. |
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