Clu

Gene Symbol	Clu
Entrez Gene	24854
Alt Symbol	APOJ, CLI, DAG, RATTRPM2B, SGP-2, SGP2, SP-40, SP40, TRPM-2, TRPM2B, Trpm2, Trpmb
Species	Rat
Gene Type	protein-coding
Description	clusterin
Other Description	dimeric acid glycoprotein|sulfated glycoprotein 2|testosterone repressed prostate message 2|testosterone-repressed prostate message|testostrone-repressed prostate message 2
Swissprots	P05371
Accessions	AAA18641 AAA42299 EDL85369 EDL85370 EDL85371 EDL85372 P05371 AF314657 AAG31162 BC061534 AAH61534 FQ209467 FQ209498 FQ209623 FQ211071 FQ213433 FQ214098 FQ218237 FQ218812 FQ219030 M16975 AAA41273 M64723 AAA42298 X13231 CAA31618 XM_006252094 XP_006252156 NM_053021 NP_444180
Function	Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promote
Subcellular Location	Secreted {ECO:0000269|PubMed:3415696, ECO:0000269|PubMed:3651384}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250}. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis (By similarity). {ECO:0000250}.
Tissue Specificity	Detected in Sertoli cells (at protein level). Detected in cultured Sertoli cells, testis, epididymis, liver and brain. {ECO:0000269|PubMed:3651384}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Clusterin (Apolipoprotein J) Rat ELISA Kit - ab190540 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 3.399 ng/ml Range 12.5 ng/ml - 800 ng/ml

Clusterin (CLU), Rat, ELISA Kit - SEB180Ra from ARP American Research Products Category ELISA Kit Prices $742.00 Sizes 96 t Sensitivity 0.57ng/mL Range 1.56-100ng/mL

Clusterin, CLU, Rat, ELISA Kit - CSB-E11860r from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Clusterin, Clu, Rat, ELISA Kit - E1180r from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 1.56-100 ng/mL

Clusterin, Rat, ELISA Kit - E02C0373 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/ml

Rat Clusterin ELISA - ELR-Clusterin from RayBiotech Category ELISA Kit Prices $560.00, $1,008.00, $2,241.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 1.3 ng/ml Range 1.3 ng/ml - 320 ng/ml

Rat CLU ELISA Kit - RC0380 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Rat Clusterin ELISA - GWB-R374CL from Genway Biotech Category ELISA Kit Prices $486.00 Sizes 96 well Sensitivity 3.399 ng/ml Range Refer To Manual

Rat Clusterin ELISA Kit - DEIA4539 from Creative Diagnostics Category ELISA Kit

RAT CLUSTERIN ELISA Kit - DEIA8514 from Creative Diagnostics Category ELISA Kit

Rat CLU(Clusterin) ELISA Kit - E-EL-R0222 from Elabscience Category ELISA Kit Sensitivity 0.94 ng/mL Range 1.56—100 ng/mL

Rat CLU (Clusterin) CLIA Kit - E-CL-R0150 from Elabscience Category CLIA Kit Sensitivity 0.19 ng/mL Range Average Recovery (%)

Rat Clusterin,CLU ELISA Kit - CSB-E11860r from Cusabio Category ELISA Kit Sensitivity 1.56 ng/ml. Range 6.25 ng/ml-400 ng/ml

Rat Clusterin ELISA - E02C0373 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Clusterin (CLU) - SEB180Ra from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.068ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Apo J/Clusterin - KBV-40020 from Nordic BioSite Sensitivity 0,7 ng/ml Range 4–128 ng/ml

Rat Clusterin (CLU) ELISA Kit - EKU03251 from Biomatik Category ELISA Kit Prices $758.00, $3,336.00, $6,065.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.068 ng/mL Range 0.156-10 ng/mL

Rat CLU(Clusterin) ELISA Kit - E-EL-R0222 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.94 ng/mL Range 1.56~100 ng/mL

Rat BLC (B-Lymphocyte Chemoattractant) CLIA Kit - E-CL-R0078 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 9.375pg/mL Range 15.625-1000pg/mL

Rat Clusterin ELISA Kit - abx256187 from Abbexa Category ELISA Kit Range 1.563 ng/ml - 100 ng/ml

Rat Clusterin ELISA Kit - abx051518 from Abbexa Category ELISA Kit Sensitivity 0.1 ng/ml Range 1 ng/ml - 80 ng/ml

Rat Clusterin ELISA Kit - abx155355 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Clusterin (CLU), Rat, ELISA Kit - DL-CLU-Ra from ARP American Research Products Category ELISA Kit Prices $715.00 Sizes 96 t Range 1.56-100 ng/mL

Custom Rat Clusterin SpeedE LISA - ELRS-Clusterin from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Rat CLU ELISA kit - orb196882 from Biorbyt Category ELISA Kit Prices $1,054.00, $1,811.00, $3,910.00 Sizes 96 assays, 192 assays, 480 assays

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