Clu

Gene Symbol	Clu
Entrez Gene	24854
Alt Symbol	APOJ, CLI, DAG, RATTRPM2B, SGP-2, SGP2, SP-40, SP40, TRPM-2, TRPM2B, Trpm2, Trpmb
Species	Rat
Gene Type	protein-coding
Description	clusterin
Other Description	dimeric acid glycoprotein|sulfated glycoprotein 2|testosterone repressed prostate message 2|testosterone-repressed prostate message|testostrone-repressed prostate message 2
Swissprots	P05371
Accessions	AAA18641 AAA42299 EDL85369 EDL85370 EDL85371 EDL85372 P05371 AF314657 AAG31162 BC061534 AAH61534 FQ209467 FQ209498 FQ209623 FQ211071 FQ213433 FQ214098 FQ218237 FQ218812 FQ219030 M16975 AAA41273 M64723 AAA42298 X13231 CAA31618 XM_006252094 XP_006252156 NM_053021 NP_444180
Function	Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promote
Subcellular Location	Secreted {ECO:0000269|PubMed:3415696, ECO:0000269|PubMed:3651384}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250}. Note=Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis (By similarity). {ECO:0000250}.
Tissue Specificity	Detected in Sertoli cells (at protein level). Detected in cultured Sertoli cells, testis, epididymis, liver and brain. {ECO:0000269|PubMed:3651384}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Clusterin Protein (OPPA00696) - OPPA00696 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Rat Clusterin Protein - abx065950 from Abbexa Category Protein Source E.coli Species Rat

Apolipoprotein J / Apo J - P5826 from Acris Antibodies Category Protein Prices $500.00 Sizes 10 µg Species Rat

Clusterin, Rat Recombinant - 228-10249-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Rat

Recombinant Rat CLU / ApoJ - 228-10249-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Rat

Recombinant Rat CLU / ApoJ - 228-10249-3 from RayBiotech Category Protein Source Escherichia Coli. Species Rat

Clusterin (CLU), Rat - 20-7522 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Rat

Clusterin Rat - CYPS-444 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Rat

Recombinant Rat CLU Protein - BP000057-CYT-437 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 10 µg, 1 mg Source E. Coli-derived. Species Rat

Recombinant Rat Clusterin, T7-His - Clu-2679R from Creative Biomart Category Protein Source E. coli .

Recombinant Rattus Clusterin, His-tagged, T7-tagged - Clu-108R from Creative Biomart Category Protein Source Escherichia Coli.

Recombinant Rat Clu, His-tagged - Clu-3664R from Creative Biomart Category Protein Source E. coli Species Rat

Clusterin Rat - BCA-971 from Reagent Proteins Category Protein Prices $348.00, $4,425.00 Sizes 10.00 µg, 1 mg Source E.coli Species Rat

Apo J/Clusterin - PPT-20034 from Nordic BioSite Category Protein Species Rat

Recombinant Clusterin (CLU) - RPB180Ra01 from Cloud-clone Category Protein Source E.coli Species Rat

Recombinant Rat Clusterin(Clu) - CSB-YP005595RA CSB-EP005595RA CSB-BP005595RA CSB-MP005595RA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Rat

Clusterin (CLU) - RPU140848 from Biomatik Category Protein Prices $209.00, $418.00, $627.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Rat

Apolipoprotein-J, Recombinant Protein - MBS142313 from MyBioSource Category Protein Prices $140.00, $205.00, $3,845.00 Sizes 2 µg, 10 µg, 1 mg Source E Coli

Clusterin Rat Recombinant ( Clusterin Rat ) - PT_40267 from Novatein Biosciences Prices $175.00, $289.00, $3,528.00 Sizes 2 µg, 10 µg, 1 mg Species Rat

Recombinant Rat CLU Protein - CLU-1472R from Creative Biomart Category Protein Source Mammalian Cells Species Rat

Clusterin Rat Recombinant - Pr20373 from ProMab Category Protein Prices $50.00, $130.00, $3,600.00 Sizes 2 μg, 10 μg, 1 mg Source Escherichia Coli. Species Rat

Recombinant Clusterin (CLU) - RPU40848 from Biomatik Category Protein Prices $167.00, $342.00, $523.00, $653.60 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Rat

CLU Recombinant Protein (OPCD02270) - OPCD02270 from Aviva Systems Biology Category Protein Source E.coli Species Rat

Clusterin (CLU), Recombinant Protein - MBS2012000 from MyBioSource Category Protein Prices $170.00, $345.00, $535.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Clusterin (Clu), Recombinant Protein - MBS1073776 from MyBioSource Category Protein Prices $1,200.00, $1,200.00, $1,420.00, $1,420.00, $1,940.00, $1,940.00, $2,405.00, $2,405.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Rat

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