| Gene Symbol | PLCG1 |
|---|---|
| Entrez Gene | 5335 |
| Alt Symbol | NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase C, gamma 1 |
| Other Description | 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-148|PLC-gamma-1|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphatidylinositol phospholipase C|phosphoinositidase C|phosphoinositide phospholipase C|phosphoinositide phospholipase C-gamma-1|phospholipase C, gamma 1 (formerly subtype 148)|phospholipase C-148|phospholipase C-II|phospholipase C-gamma-1|triphosphoinositide phosphodiesterase |
| Swissprots | E1P5W4 Q2V575 B9EGH4 B7ZLY7 P19174 |
| Accessions | AAB70663 ABB84466 EAW75989 EAW75990 EAW75991 EAW75992 EAW75993 P19174 AB210028 BAE06110 AF147391 AK297370 BAG59815 AK309606 AL110247 CAB53696 BC136466 AAI36467 BC144136 AAI44137 BX415739 BX434193 M34667 AAA36452 XM_005260438 XP_005260495 XM_011528865 XP_011527167 XM_011528866 XP_011527168 XM_011528867 XP_011527169 XR_936550 NM_002660 NP_002651 NM_182811 NP_877963 |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:17229814}. |
| Subcellular Location | Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. |
| Top Pathways | Epstein-Barr virus infection, MicroRNAs in cancer, Inflammatory mediator regulation of TRP channels, Choline metabolism in cancer, Rap1 signaling pathway |
Human PLCG1 ELISA Kit (Sandwich ELISA) - LS-F4829 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-PLCG1 (Tyr771) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1093 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-PLCG1 (Tyr783) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1094 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-PLCG1 (Tyr1253) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1209 from LifeSpan Bioscience
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Mouse/Human/Rat PLCG1 ELISA Kit (Cell-Based ELISA) - LS-F2258 from LifeSpan Bioscience
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Human PLCG1 ELISA Kit (Sandwich ELISA) - LS-F12344 from LifeSpan Bioscience
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Human PLCg1 ELISA Kit - abx152774 from Abbexa
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1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma-1 (PLCG1), Human, ELISA Kit - E01P0910 from ARP American Research Products
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1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1, PLCG1, Human, ELISA Kit - E0269h from ARP American Research Products
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Phospholipase C Gamma 1 (PLCg1), Human, ELISA Kit - SEA269Hu from ARP American Research Products
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Phospholipase C Gamma 1, PLCy1, Human, ELISA Kit - E-EL-H1718 from ARP American Research Products
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Phospholipase C Gamma 1, PLCg1, Mouse, ELISA Kit - E-EL-M0904 from ARP American Research Products
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Phospholipase C Gamma 1, PLCg1, Rat, ELISA Kit - E-EL-R0735 from ARP American Research Products
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Phospholipase C Gamma 1, PLCy1, Rabbit, ELISA Kit - E-EL-RB1850 from ARP American Research Products
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Phospholipase C Gamma 1, PLCy1, Chicken, ELISA Kit - E-EL-Ch0275 from ARP American Research Products
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Phospholipase C Gamma 1, PLCy1, Porcine, ELISA Kit - E-EL-P1900 from ARP American Research Products
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Phospholipase C Gamma 1, PLCy1, Sheep, ELISA Kit - E-EL-S0386 from ARP American Research Products
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Phospholipase C Gamma 1, PLCy1, Monkey, ELISA Kit - E-EL-MK1877 from ARP American Research Products
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Human PLCg1 ELISA Kit - HP0133 from NeoScientific
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Anserine PLCg1 ELISA Kit - AP0133 from NeoScientific
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PLCG1 Colorimetric Cell-Based ELISA Kit - CB5574 from Assay Biotechnology
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PLCG1 (Phospho-Tyr771) Colorimetric Cell-Based ELISA Kit - CBP1072 from Assay Biotechnology
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PLCG1 (Phospho-Tyr783) Colorimetric Cell-Based ELISA Kit - CBP1073 from Assay Biotechnology
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PLCG1 (Phospho-Tyr1253) Colorimetric Cell-Based ELISA Kit - CBP1202 from Assay Biotechnology
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ELISA Kit for Phospholipase C Gamma 1 (PLCg1) - SEA269Hu from Uscn Life Science Inc.
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