| Gene Symbol |
PLCG1
|
| Entrez Gene |
5335
|
| Alt Symbol |
NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, gamma 1
|
| Other Description |
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-148|PLC-gamma-1|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphatidylinositol phospholipase C|phosphoinositidase C|phosphoinositide phospholipase C|phosphoinositide phospholipase C-gamma-1|phospholipase C, gamma 1 (formerly subtype 148)|phospholipase C-148|phospholipase C-II|phospholipase C-gamma-1|triphosphoinositide phosphodiesterase
|
| Swissprots |
E1P5W4 Q2V575 B9EGH4 B7ZLY7 P19174
|
| Accessions |
AAB70663 ABB84466 EAW75989 EAW75990 EAW75991 EAW75992 EAW75993 P19174 AB210028 BAE06110 AF147391 AK297370 BAG59815 AK309606 AL110247 CAB53696 BC136466 AAI36467 BC144136 AAI44137 BX415739 BX434193 M34667 AAA36452 XM_005260438 XP_005260495 XM_011528865 XP_011527167 XM_011528866 XP_011527168 XM_011528867 XP_011527169 XR_936550 NM_002660 NP_002651 NM_182811 NP_877963
|
| Function |
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:17229814}.
|
| Subcellular Location |
Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
|
| Top Pathways |
Epstein-Barr virus infection, MicroRNAs in cancer, Inflammatory mediator regulation of TRP channels, Choline metabolism in cancer, Rap1 signaling pathway
|