PLCG1

Gene Symbol	PLCG1
Entrez Gene	5335
Alt Symbol	NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
Species	Human
Gene Type	protein-coding
Description	phospholipase C, gamma 1
Other Description	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1|PLC-148|PLC-gamma-1|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphatidylinositol phospholipase C|phosphoinositidase C|phosphoinositide phospholipase C|phosphoinositide phospholipase C-gamma-1|phospholipase C, gamma 1 (formerly subtype 148)|phospholipase C-148|phospholipase C-II|phospholipase C-gamma-1|triphosphoinositide phosphodiesterase
Swissprots	E1P5W4 Q2V575 B9EGH4 B7ZLY7 P19174
Accessions	AAB70663 ABB84466 EAW75989 EAW75990 EAW75991 EAW75992 EAW75993 P19174 AB210028 BAE06110 AF147391 AK297370 BAG59815 AK309606 AL110247 CAB53696 BC136466 AAI36467 BC144136 AAI44137 BX415739 BX434193 M34667 AAA36452 XM_005260438 XP_005260495 XM_011528865 XP_011527167 XM_011528866 XP_011527168 XM_011528867 XP_011527169 XR_936550 NM_002660 NP_002651 NM_182811 NP_877963
Function	Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. {ECO:0000269|PubMed:17229814}.
Subcellular Location	Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Top Pathways	Epstein-Barr virus infection, MicroRNAs in cancer, Inflammatory mediator regulation of TRP channels, Choline metabolism in cancer, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Phospholipase C gamma 1 (phospho Y775) peptide - ab42756 from Abcam Category Peptide Species Human

Human Phospholipase C gamma 1 protein fragment - ab112339 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human PLC-gamma 1 Protein - H00005335-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PLCG1 peptide - orb217761 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

Human PLCg1 Protein - abx068542 from Abbexa Category Protein Source E.coli Species Human

PLCG1 - H00005335-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLCG1 - H00005335-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLCG1+PLCG2 Control Peptide - AP00342CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

PLC 1 (Phospho-Tyr783) Antibody Blocking Peptide - GWB-BF36CE from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

PLC 2(Phospho-Tyr753) Antibody Blocking Peptide - GWB-3FD35C from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Recombinant Human PLCG1 - PLCG1-30735TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PLCG1, MYC/DDK-tagged - PLCG1-17H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Phospholipase C Gamma 1 (PLCg1) - RPA269Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

PLC gamma 1 (pY1253) Blocking Peptide - CBP1896 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

PLC gamma 1 Blocking Peptide - CBP1897 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Monkey

PLC gamma 1 Blocking Peptide - CBP1898 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

PLC gamma 1 (pY783) Blocking Peptide - CBP3290 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

PLC γ1 (G777) Peptide - BS1295P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

PLC γ1 (G765) Peptide - BS1709P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-PLC γ1 (Y783) Peptide - BS4157P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-PLC γ1 (Y771) Peptide - BS4463P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-PLC γ1 (Y1253) Peptide - BS4865P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

PLC γ1 (G1247) Peptide - BS9114P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Phospholipase C Gamma 1 (PLCg1) - RPA269Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1(PLCG1) ,partial - CSB-YP018134HU CSB-EP018134HU CSB-BP018134HU CSB-MP018134HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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