CDKN1A

Gene Symbol CDKN1A
Entrez Gene 1026
Alt Symbol CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Other Description CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1
Swissprots Q9BUT4 Q14010 Q6FI05 P38936
Accessions AAM11787 CAJ98559 CAJ98560 CBX54345 EAX03904 EAX03905 EAX03906 EAX03907 P38936 AA534613 AB209881 BAD93118 AB451290 BAG70104 AB451422 BAG70236 AI973138 AK298901 BAG61011 AK309512 AM392711 CAL37589 AM392920 CAL37798 BC000275 AAH00275 BC000312 AAH00312 BC001935 AAH01935 BC013967 AAH13967 BQ941282 BT006719 AAP35365 BU154329 BU193165 CR536533 CAG38770 DA552678 DA582789 DA699672 DA702185 DA838987 L25610 AAA16109 L26165 AAA19811 L47232 AAB59559 L47233 AAB59560 S67388 AAB29246 U03106 AAC04313 U09579 AAA85641 NM_000389 NP_000380 NM_001220777 NP_001207706 NM_001220778 NP_001207707 NM_001291549 NP_001278478 NM_078467 NP_510867
Function May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
Top Pathways HTLV-I infection, MicroRNAs in cancer, Epstein-Barr virus infection, Oxytocin signaling pathway, Proteoglycans in cancer

PathScan ® Total p21 Waf1/Cip1 Sandwich ELISA Antibody Pair - 7856 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Total p21 Waf1/Cip1 Sandwich ELISA Kit - 7167 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

SimpleChIP ® Human CDKN1A Promoter Primers - 6449 from Cell Signaling Technology

Category ChIP Kit
Prices $102.00
Sizes 500 µl (250 PCR reactions)
SimpleChIP ® Human CDKN1A Promoter Primers were tested on DNA isolated from cross-linked cells using the SimpleChIP ® Enzymatic Chromatin IP Kit (Magnetic Beads) #9003. Real-time PCR was performed in duplicate on a serial dilution of 2% total input DNA (20 ng, 4 ng, 0.8 ng, and 0.16 ng) using a real-time PCR detection system and SYBR ® Green reaction mix. The PCR amplification efficiency (E) and correlation coefficient (R 2 ) were calculated based on the corresponding threshold cycle (C T ) of each dilution sample during 40 cycles of real-time PCR (95°C denaturation for 15 sec, 65°C anneal/extension for 60 sec).

SimpleChIP ® Human CDKN1A Intron 1 Primers - 4669 from Cell Signaling Technology

Category ChIP Kit
Prices $102.00
Sizes 500 µl (250 PCR reactions)
SimpleChIP ® Human CDKN1A Intron 1 Primers were tested on DNA isolated from cross-linked cells using the SimpleChIP ® Enzymatic Chromatin IP Kit (Magnetic Beads) #9003. Real-time PCR was performed in duplicate on a serial dilution of 2% total input DNA (20 ng, 4 ng, 0.8 ng, and 0.16 ng) using a real-time PCR detection system and SYBR ® Green reaction mix. The PCR amplification efficiency (E) and correlation coefficient (R 2 ) were calculated based on the corresponding threshold cycle (C T ) of each dilution sample during 40 cycles of real-time PCR (95°C denaturation for 15 sec, 60°C anneal/extension for 60 sec).

p21 Human SimpleStep ELISA™ Kit - ab171579 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity 33 pg/ml
Range 0.31 ng/ml - 20 ng/ml
Background-subtracted data values (mean +/- SD) are graphed.

Rat CDKN1A / WAF1 / p21 ELISA Kit (Sandwich ELISA) - LS-F6933 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-CDKN1A / WAF1 / p21 (Thr145) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1584 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.156-10 ng/ml

Mouse/Human/Rat CDKN1A / WAF1 / p21 ELISA Kit (Cell-Based ELISA) - LS-F2202 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.156-10 ng/ml

Human Total p21/CIP1/CDKN1A DuoSet IC ELISA - DYC1047-2 from R&D Systems

Category ELISA Kit
Prices $329.00, $649.00, $1,395.00
Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)
Range 62.50 - 4,000 pg/mL

Cyclin Dependent Kinase 16 (CDK16), Human, ELISA Kit - SEE620Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 12.6pg/mL
Range 31.2-2,000pg/mL

Cyclin-dependent kinase inhibitor 1 (CDKN1A), Human, ELISA Kit - CSB-EL005086HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 7.81 pg/ml
Range 31.25 pg/ml-2000 pg/ml

P21 ELISA Kit - KE00049 from Acris Antibodies

Category ELISA Kit
Prices $599.00
Sizes 1 kit
Range 0.1 ng/ml

Human P21 ELISA Kit - KE00049 from Proteintech Group

Category ELISA Kit
Prices $599.00
Sizes 1
Sensitivity 0.1 ng/mL
Range 0.25 ng/mL - 16 ng/mL

CDKN1A, ELISA Kit - MBS2501291 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 46.875pg/mL
Range 78.125-5000pg/mL

CDKN1A, ELISA Kit - MBS2510310 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156-10ng/mL

Cyclin Dependent Kinase Inhibitor 1A (CDKN1A), ELISA Kit - MBS2019085 from MyBioSource

Category ELISA Kit
Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.068ng/mL.
Range 0.156-10ng/mL

cyclin-dependent kinase inhibitor 1A (p21, Cip1) , ELISA Kit - MBS943311 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 7.81 pg/ml
Range 31.25 pg/ml-2000 pg/ml

p21 Cip1 Colorimetric Cell-Based ELISA Kit - CB5510 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

p21 Cip1 (Phospho-Thr145) Colorimetric Cell-Based ELISA Kit - CBP1637 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Antioncogene P21 Protein, ELISA Kit - MBS014593 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antioncogene P21 Protein, ELISA Kit - MBS019201 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antioncogene p21 protein, ELISA Kit - MBS728854 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Antioncogene P21 Protein, ELISA Kit - MBS005414 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Search more