CDKN1A

Gene Symbol	CDKN1A
Entrez Gene	1026
Alt Symbol	CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Other Description	CDK-interacting protein 1|CDK-interaction protein 1|DNA synthesis inhibitor|cyclin-dependent kinase inhibitor 1|melanoma differentiation associated protein 6|wild-type p53-activated fragment 1
Swissprots	Q9BUT4 Q14010 Q6FI05 P38936
Accessions	AAM11787 CAJ98559 CAJ98560 CBX54345 EAX03904 EAX03905 EAX03906 EAX03907 P38936 AA534613 AB209881 BAD93118 AB451290 BAG70104 AB451422 BAG70236 AI973138 AK298901 BAG61011 AK309512 AM392711 CAL37589 AM392920 CAL37798 BC000275 AAH00275 BC000312 AAH00312 BC001935 AAH01935 BC013967 AAH13967 BQ941282 BT006719 AAP35365 BU154329 BU193165 CR536533 CAG38770 DA552678 DA582789 DA699672 DA702185 DA838987 L25610 AAA16109 L26165 AAA19811 L47232 AAB59559 L47233 AAB59560 S67388 AAB29246 U03106 AAC04313 U09579 AAA85641 NM_000389 NP_000380 NM_001220777 NP_001207706 NM_001220778 NP_001207707 NM_001291549 NP_001278478 NM_078467 NP_510867
Function	May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:8242751, ECO:0000269|PubMed:9106657}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
Top Pathways	HTLV-I infection, MicroRNAs in cancer, Epstein-Barr virus infection, Oxytocin signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® p21 Waf1/Cip1 siRNA I - 6456 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections) Species Reactivities Human

SignalSilence ® p21 Waf1/Cip1 siRNA II - 6558 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

p21 CRISPR/Cas9 KO Plasmid (h) - sc-400013 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 HDR Plasmid (h) - sc-400013-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 Double Nickase Plasmid (h) - sc-400013-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 Double Nickase Plasmid (h2) - sc-400013-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 CRISPR Activation Plasmid (h) - sc-400013-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 CRISPR Activation Plasmid (h2) - sc-400013-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 Lentiviral Activation Particles (h) - sc-400013-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 Lentiviral Activation Particles (h2) - sc-400013-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p21 siRNA (h) - sc-29427 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p21 shRNA Plasmid (h) - sc-29427-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p21 shRNA (h) Lentiviral Particles - sc-29427-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p21 siRNA (h2) - sc-44214 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p21 shRNA Plasmid (h2) - sc-44214-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p21 shRNA (h2) Lentiviral Particles - sc-44214-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU003861 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN1493 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1493 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CDKN1A siRNA (Human) - CRH0738 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

p21/CIP1/CDKN1A RNAi - H00001026-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CDKN1A - MBS8235095 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CDKN1A (NM_000389.4) - SHH260809 from Creative biogene Category siRNA Species Reactivities Human

Human CDKN1A siRNA - orb261240 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CDKN1A shRNA Plasmid (Human) - CHH0738 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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