| Gene Symbol | STMN2 |
|---|---|
| Entrez Gene | 11075 |
| Alt Symbol | SCG10, SCGN10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | stathmin 2 |
| Other Description | neuron-specific growth-associated protein|neuronal growth-associated protein (silencer element)|stathmin-2|stathmin-like 2|superior cervical ganglia, neural specific 10|superior cervical ganglion-10 protein |
| Swissprots | O14952 Q6PK68 G3V110 A8K9M2 Q93045 |
| Accessions | EAW87063 EAW87064 EAW87065 Q93045 AI096716 AK091336 AK292737 BAF85426 AK297485 BAH12589 AK297594 BAH12622 AK299500 BAH13053 AK308557 AK309130 AL110174 BC006302 AAH06302 BQ069488 BT020034 AAV38837 CR456833 CAG33114 D50375 BAA23326 DC319376 DQ892719 ABM83645 DQ895968 ABM86894 S82024 AAB36428 XM_005251142 XP_005251199 NM_001199214 NP_001186143 NM_007029 NP_008960 |
| Function | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon. Golgi apparatus. Endosome {ECO:0000250}. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. {ECO:0000250}. |
| Tissue Specificity | Neuron specific. |
SCG10 CRISPR/Cas9 KO Plasmid (h) - sc-404807 from Santa Cruz Biotechnology
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SCG10 HDR Plasmid (h) - sc-404807-HDR from Santa Cruz Biotechnology
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SCG10 Double Nickase Plasmid (h) - sc-404807-NIC from Santa Cruz Biotechnology
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SCG10 Double Nickase Plasmid (h2) - sc-404807-NIC-2 from Santa Cruz Biotechnology
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SCG10 CRISPR Activation Plasmid (h) - sc-404807-ACT from Santa Cruz Biotechnology
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SCG10 CRISPR Activation Plasmid (h2) - sc-404807-ACT-2 from Santa Cruz Biotechnology
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SCG10 Lentiviral Activation Particles (h) - sc-404807-LAC from Santa Cruz Biotechnology
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SCG10 Lentiviral Activation Particles (h2) - sc-404807-LAC-2 from Santa Cruz Biotechnology
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SCG10 siRNA (h) - sc-40782 from Santa Cruz Biotechnology
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SCG10 shRNA Plasmid (h) - sc-40782-SH from Santa Cruz Biotechnology
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SCG10 shRNA (h) Lentiviral Particles - sc-40782-V from Santa Cruz Biotechnology
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Stathmin-2/STMN2 RNAi - H00011075-R01 from Novus Biologicals
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MISSION® esiRNA - EHU011981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20749 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20749 from Sigma-Aldrich
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STMN2 siRNA (Human) - CRH7572 from Cohesion Biosciences
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STMN2 - MBS8213476 from MyBioSource
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shRNA set against Human STMN2 (NM_007029.3) - SHH419944 from Creative biogene
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Human STMN2 siRNA - orb268074 from Biorbyt
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STMN2 shRNA Plasmid (Human) - CHH7572 from Cohesion Biosciences
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STMN2 miRNA 3'UTR clone - MiUTR3H-03526 from Creative biogene
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