| Gene Symbol |
Hemgn
|
| Entrez Gene |
93966
|
| Alt Symbol |
4921524M03Rik, AI317176, EDAG, Hgn, mNDR
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
hemogen
|
| Other Description |
hemopoietic gene protein|negative differentiation regulator protein|nuclear protein
|
| Swissprots |
Q80YT2 Q3TAE6 B1AVH8 Q9ERZ0 Q8CF29
|
| Accessions |
ABB17039 EDL02369 EDL02370 Q9ERZ0 AF269248 AAG33367 AK006588 BAC25148 AK076587 AK077692 BAC36959 AK156536 BAE33747 AK171890 BAE42722 AK171906 AK172421 AY699986 AAT94243 BC050798 AAH50798 XM_011250137 XP_011248439 NM_053149 NP_444379
|
| Function |
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11404085}.
|
| Tissue Specificity |
Expressed in hematopoietic precursor cells. Highly expressed in bone marrow, the red pulp of the spleen and round spermatids. Weakly expressed in peripheral blood cells. {ECO:0000269|PubMed:11404085, ECO:0000269|PubMed:14648837}.
|
