Gene Symbol | Hemgn |
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Entrez Gene | 93966 |
Alt Symbol | 4921524M03Rik, AI317176, EDAG, Hgn, mNDR |
Species | Mouse |
Gene Type | protein-coding |
Description | hemogen |
Other Description | hemopoietic gene protein|negative differentiation regulator protein|nuclear protein |
Swissprots | Q80YT2 Q3TAE6 B1AVH8 Q9ERZ0 Q8CF29 |
Accessions | ABB17039 EDL02369 EDL02370 Q9ERZ0 AF269248 AAG33367 AK006588 BAC25148 AK076587 AK077692 BAC36959 AK156536 BAE33747 AK171890 BAE42722 AK171906 AK172421 AY699986 AAT94243 BC050798 AAH50798 XM_011250137 XP_011248439 NM_053149 NP_444379 |
Function | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11404085}. |
Tissue Specificity | Expressed in hematopoietic precursor cells. Highly expressed in bone marrow, the red pulp of the spleen and round spermatids. Weakly expressed in peripheral blood cells. {ECO:0000269|PubMed:11404085, ECO:0000269|PubMed:14648837}. |
Hemogen CRISPR/Cas9 KO Plasmid (m) - sc-430089 from Santa Cruz Biotechnology
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Hemogen HDR Plasmid (m) - sc-430089-HDR from Santa Cruz Biotechnology
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Hemogen Double Nickase Plasmid (m) - sc-430089-NIC from Santa Cruz Biotechnology
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Hemogen Double Nickase Plasmid (m2) - sc-430089-NIC-2 from Santa Cruz Biotechnology
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Hemogen CRISPR Activation Plasmid (m) - sc-430089-ACT from Santa Cruz Biotechnology
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Hemogen CRISPR Activation Plasmid (m2) - sc-430089-ACT-2 from Santa Cruz Biotechnology
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Hemogen Lentiviral Activation Particles (m) - sc-430089-LAC from Santa Cruz Biotechnology
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Hemogen Lentiviral Activation Particles (m2) - sc-430089-LAC-2 from Santa Cruz Biotechnology
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Hemogen siRNA (m) - sc-61860 from Santa Cruz Biotechnology
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Hemogen shRNA Plasmid (m) - sc-61860-SH from Santa Cruz Biotechnology
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Hemogen shRNA (m) Lentiviral Particles - sc-61860-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU089671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33178 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33178 from Sigma-Aldrich
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HEMGN siRNA (Mouse) - CRN0283 from Cohesion Biosciences
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HEMGN - MBS8234185 from MyBioSource
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shRNA set against Mouse HEMGN (NM_053149.2) - SHH311493 from Creative biogene
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shRNA set against Mouse Hemgn(NM_053149.2) - SHH118145 from Creative biogene
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Mouse HEMGN siRNA - orb289758 from Biorbyt
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HEMGN shRNA Plasmid (Mouse) - CHN0283 from Cohesion Biosciences
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HEMGN miRNA 3'UTR clone - MiUTR1M-05596 from Creative biogene
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