| Gene Symbol |
IFI30
|
| Entrez Gene |
10437
|
| Alt Symbol |
GILT, IFI-30, IP-30, IP30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon, gamma-inducible protein 30
|
| Other Description |
gamma-interferon-inducible lysosomal thiol reductase|gamma-interferon-inducible protein IP-30|interferon gamma-inducible protein 30 preproprotein|legumaturain
|
| Swissprots |
Q8WU77 Q76MF9 P13284 Q9UL08 Q8NEI4
|
| Accessions |
AAD22672 EAW84661 EAW84662 EAW84663 EAW84664 EAW84665 EAW84666 P13284 AB049659 BAC98466 AF097362 AAF04618 AF401212 AAL02170 AI022513 AK123477 AK291551 BAF84240 AL558891 BC021136 AAH21136 BC031020 AAH31020 BE515053 DQ884410 ABI63377 DQ892016 ABM82942 DQ895206 ABM86132 NM_006332 NP_006323
|
| Function |
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted. Lysosome.
|
| Top Pathways |
Antigen processing and presentation
|
