Gene Symbol | IFI30 |
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Entrez Gene | 10437 |
Alt Symbol | GILT, IFI-30, IP-30, IP30 |
Species | Human |
Gene Type | protein-coding |
Description | interferon, gamma-inducible protein 30 |
Other Description | gamma-interferon-inducible lysosomal thiol reductase|gamma-interferon-inducible protein IP-30|interferon gamma-inducible protein 30 preproprotein|legumaturain |
Swissprots | Q8WU77 Q76MF9 P13284 Q9UL08 Q8NEI4 |
Accessions | AAD22672 EAW84661 EAW84662 EAW84663 EAW84664 EAW84665 EAW84666 P13284 AB049659 BAC98466 AF097362 AAF04618 AF401212 AAL02170 AI022513 AK123477 AK291551 BAF84240 AL558891 BC021136 AAH21136 BC031020 AAH31020 BE515053 DQ884410 ABI63377 DQ892016 ABM82942 DQ895206 ABM86132 NM_006332 NP_006323 |
Function | Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. Lysosome. |
Top Pathways | Antigen processing and presentation |
GILT CRISPR/Cas9 KO Plasmid (h) - sc-404810 from Santa Cruz Biotechnology
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GILT HDR Plasmid (h) - sc-404810-HDR from Santa Cruz Biotechnology
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GILT Double Nickase Plasmid (h) - sc-404810-NIC from Santa Cruz Biotechnology
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GILT Double Nickase Plasmid (h2) - sc-404810-NIC-2 from Santa Cruz Biotechnology
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GILT CRISPR Activation Plasmid (h) - sc-404810-ACT from Santa Cruz Biotechnology
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GILT CRISPR Activation Plasmid (h2) - sc-404810-ACT-2 from Santa Cruz Biotechnology
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GILT Lentiviral Activation Particles (h) - sc-404810-LAC from Santa Cruz Biotechnology
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GILT Lentiviral Activation Particles (h2) - sc-404810-LAC-2 from Santa Cruz Biotechnology
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GILT siRNA (h) - sc-39522 from Santa Cruz Biotechnology
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GILT shRNA Plasmid (h) - sc-39522-SH from Santa Cruz Biotechnology
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GILT shRNA (h) Lentiviral Particles - sc-39522-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU228311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10460 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10460 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00531 from Sigma-Aldrich
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IFI30 siRNA (Human) - CRH7079 from Cohesion Biosciences
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IFI30 - MBS8218875 from MyBioSource
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shRNA set against Human IFI30 (NM_006332.3) - SHH316837 from Creative biogene
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shRNA set against Human IFI30(NM_006332.3) - SHL165702 from Creative biogene
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IFI30 shRNA Plasmid (Human) - CHH7079 from Cohesion Biosciences
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IFI30 miRNA 3'UTR clone - MiUTR1H-04799 from Creative biogene
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