Gene Symbol | BHLHA15 |
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Entrez Gene | 168620 |
Alt Symbol | BHLHB8, MIST1 |
Species | Human |
Gene Type | protein-coding |
Description | basic helix-loop-helix family, member a15 |
Other Description | MIST-1|basic helix-loop-helix domain containing, class B, 8|class A basic helix-loop-helix protein 15|class B basic helix-loop-helix protein 8|class II bHLH protein MIST1|muscle, intestine and stomach expression 1 |
Swissprots | A4D271 Q14DE4 Q7RTS1 |
Accessions | EAL23893 Q7RTS1 BC113394 AAI13395 BC113396 AAI13397 BK000276 DAA01056 BX648200 NM_177455 NP_803238 |
Function | Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250|UniProtKB:Q9QYC3}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed in brain, liver, spleen and skeletal muscle. {ECO:0000269|PubMed:14516699}. |
Top Pathways | Maturity onset diabetes of the young |
MIST1 CRISPR/Cas9 KO Plasmid (h) - sc-402094 from Santa Cruz Biotechnology
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MIST1 HDR Plasmid (h) - sc-402094-HDR from Santa Cruz Biotechnology
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MIST1 Double Nickase Plasmid (h) - sc-402094-NIC from Santa Cruz Biotechnology
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MIST1 Double Nickase Plasmid (h2) - sc-402094-NIC-2 from Santa Cruz Biotechnology
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MIST1 CRISPR Activation Plasmid (h) - sc-402094-ACT from Santa Cruz Biotechnology
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MIST1 CRISPR Activation Plasmid (h2) - sc-402094-ACT-2 from Santa Cruz Biotechnology
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MIST1 Lentiviral Activation Particles (h) - sc-402094-LAC from Santa Cruz Biotechnology
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MIST1 Lentiviral Activation Particles (h2) - sc-402094-LAC-2 from Santa Cruz Biotechnology
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MIST1 siRNA (h) - sc-89777 from Santa Cruz Biotechnology
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MIST1 shRNA Plasmid (h) - sc-89777-SH from Santa Cruz Biotechnology
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MIST1 shRNA (h) Lentiviral Particles - sc-89777-V from Santa Cruz Biotechnology
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MIST1 RNAi - H00168620-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN3964 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3964 from Sigma-Aldrich
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BHLHA15 siRNA (Human) - CRJ6077 from Cohesion Biosciences
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BHLHA15 - MBS8214694 from MyBioSource
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shRNA set against Human BHLHA15 (NM_177455.3) - SHH246546 from Creative biogene
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shRNA set against Human BHLHB8(NM_177455.3) - SHG100261 from Creative biogene
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Human BHLHA15 siRNA - orb276578 from Biorbyt
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BHLHA15 shRNA Plasmid (Human) - CHJ6077 from Cohesion Biosciences
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BHLHA15 miRNA 3'UTR clone - MiUTR1H-00883 from Creative biogene
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