| Gene Symbol |
RAB25
|
| Entrez Gene |
57111
|
| Alt Symbol |
CATX-8, RAB11C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB25, member RAS oncogene family
|
| Other Description |
ras-related protein Rab-25
|
| Swissprots |
Q96GB1 Q8NG24 Q9BT12 Q5VYA2 P57735
|
| Accessions |
EAW53003 P57735 AF083124 AAF98238 AF274025 AAM69362 BC004416 AAH04416 BC009831 AAH09831 BC033322 AAH33322 EU831992 ACE87433 EU832085 ACE86747 HQ448660 ADQ33138 NM_020387 NP_065120
|
| Function |
Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). {ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629, ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, pseudopodium membrane {ECO:0000269|PubMed:17925226}. Cytoplasmic vesicle {ECO:0000269|PubMed:17925226}. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. {ECO:0000269|PubMed:17925226}.
|
| Tissue Specificity |
Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue. {ECO:0000269|PubMed:15502842}.
|