Gene Symbol | MCHR1 |
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Entrez Gene | 2847 |
Alt Symbol | GPR24, MCH-1R, MCH1R, SLC-1, SLC1 |
Species | Human |
Gene Type | protein-coding |
Description | melanin-concentrating hormone receptor 1 |
Other Description | G protein-coupled receptor 24|MCH receptor 1|somatostatin receptor-like protein |
Swissprots | Q9BV08 Q5R3J1 Q96S47 B2RBX6 Q99705 |
Accessions | AAC14587 EAW60387 EAW60388 Q99705 AB063174 BAB60890 AF490537 AAO14670 AI934819 AK308739 AK314857 BAG37373 AY562945 AAS72373 AY745811 AAV98052 AY747629 AAV98053 BC001736 AAH01736 BC021146 AAH21146 BT006725 AAP35371 CR456497 CAG30383 CU013094 CAK54525 CU013382 CAK54824 DQ893603 ABM84529 DQ895065 ABM85991 NM_005297 NP_005288 |
Function | Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10421367}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. |
Top Pathways | Neuroactive ligand-receptor interaction |
MCH-1R CRISPR/Cas9 KO Plasmid (h) - sc-402512 from Santa Cruz Biotechnology
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MCH-1R HDR Plasmid (h) - sc-402512-HDR from Santa Cruz Biotechnology
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MCH-1R Double Nickase Plasmid (h) - sc-402512-NIC from Santa Cruz Biotechnology
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MCH-1R Double Nickase Plasmid (h2) - sc-402512-NIC-2 from Santa Cruz Biotechnology
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MCH-1R CRISPR Activation Plasmid (h) - sc-402512-ACT from Santa Cruz Biotechnology
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MCH-1R CRISPR Activation Plasmid (h2) - sc-402512-ACT-2 from Santa Cruz Biotechnology
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MCH-1R Lentiviral Activation Particles (h) - sc-402512-LAC from Santa Cruz Biotechnology
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MCH-1R Lentiviral Activation Particles (h2) - sc-402512-LAC-2 from Santa Cruz Biotechnology
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MCH-1R siRNA (h) - sc-42017 from Santa Cruz Biotechnology
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MCH-1R shRNA Plasmid (h) - sc-42017-SH from Santa Cruz Biotechnology
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MCH-1R shRNA (h) Lentiviral Particles - sc-42017-V from Santa Cruz Biotechnology
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MCHR1 RNAi - H00002847-R02 from Novus Biologicals
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MISSION® esiRNA - EHU056001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13113 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13113 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06487 from Sigma-Aldrich
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MCHR1 siRNA (Human) - CRH1910 from Cohesion Biosciences
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MCH-1R CRISPR/Cas9 KO Plasmid (h2) - sc-402512-KO-2 from Santa Cruz Biotechnology
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MCH-1R HDR Plasmid (h2) - sc-402512-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human MCHR1 (NM_005297.3) - SHH339235 from Creative biogene
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shRNA set against Human MCHR1(NM_005297.3) - SHH181091 from Creative biogene
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Human MCHR1 siRNA - orb262412 from Biorbyt
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MCHR1 shRNA Plasmid (Human) - CHH1910 from Cohesion Biosciences
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MCHR1 miRNA 3'UTR clone - MiUTR1H-06161 from Creative biogene
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