UBA52
| Gene Symbol | UBA52 |
|---|---|
| Entrez Gene | 7311 |
| Alt Symbol | CEP52, HUBCEP52, L40, RPL40 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin A-52 residue ribosomal protein fusion product 1 |
| Other Description | 60S ribosomal protein L40|ubiquitin carboxyl extension protein 52|ubiquitin-52 amino acid fusion protein|ubiquitin-60S ribosomal protein L40|ubiquitin-CEP52 |
| Swissprots | P14793 P62987 |
| Accessions | AAC25582 ABE96835 CAA40312 EAW84715 EAW84716 EAW84717 EAW84718 P62987 AF348700 AAK31162 AF545864 AAP97731 AK057790 AK314717 BAG37261 BC101830 AAI01831 BC101832 AAI01833 BC143668 AAI43669 BQ428515 BQ428688 BU677484 CB124676 D28425 BAA05791 X56998 CAA40313 X56999 CAA40314 Y00361 CAA68439 XM_005260051 XP_005260108 XM_005260052 XP_005260109 XM_005260053 XP_005260110 XM_005260054 XP_005260111 XM_006722871 XP_006722934 NM_001033930 NP_001029102 NM_003333 NP_003324 |
| Function | Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac |
| Subcellular Location | Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Top Pathways | Ribosome |
UBA52 CRISPR/Cas9 KO Plasmid (h) - sc-418222 from Santa Cruz Biotechnology
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UBA52 HDR Plasmid (h) - sc-418222-HDR from Santa Cruz Biotechnology
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UBA52 Double Nickase Plasmid (h) - sc-418222-NIC from Santa Cruz Biotechnology
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UBA52 Double Nickase Plasmid (h2) - sc-418222-NIC-2 from Santa Cruz Biotechnology
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UBA52 CRISPR Activation Plasmid (h) - sc-418222-ACT from Santa Cruz Biotechnology
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UBA52 CRISPR Activation Plasmid (h2) - sc-418222-ACT-2 from Santa Cruz Biotechnology
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UBA52 Lentiviral Activation Particles (h) - sc-418222-LAC from Santa Cruz Biotechnology
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UBA52 Lentiviral Activation Particles (h2) - sc-418222-LAC-2 from Santa Cruz Biotechnology
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UBA52 siRNA (h) - sc-106653 from Santa Cruz Biotechnology
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UBA52 shRNA Plasmid (h) - sc-106653-SH from Santa Cruz Biotechnology
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UBA52 shRNA (h) Lentiviral Particles - sc-106653-V from Santa Cruz Biotechnology
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UBA52 RNAi - H00007311-R01 from Novus Biologicals
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MISSION® esiRNA - EHU223871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22340 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22340 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12894 from Sigma-Aldrich
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UBA52 siRNA (Human) - CRH4998 from Cohesion Biosciences
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UBA52 RNAi - H00007311-R02 from Novus Biologicals
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UBA52 - MBS829770 from MyBioSource |
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UBA52 - MBS8235905 from MyBioSource |
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UBA52 - MBS8238031 from MyBioSource |
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shRNA set against Human UBA52 (NM_003333.3) - SHH438684 from Creative biogene
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shRNA set against Human UBA52(NM_001033930.1) - SHL109686 from Creative biogene
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Human UBA52 siRNA - orb265500 from Biorbyt
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UBA52 shRNA Plasmid (Human) - CHH4998 from Cohesion Biosciences
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