AOC3
| Gene Symbol | AOC3 |
|---|---|
| Entrez Gene | 8639 |
| Alt Symbol | HPAO, SSAO, VAP-1, VAP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | amine oxidase, copper containing 3 |
| Other Description | amine oxidase, copper containing 3 (vascular adhesion protein 1)|copper amine oxidase|membrane primary amine oxidase|placenta copper monamine oxidase|semicarbazide-sensitive amine oxidase |
| Swissprots | Q16853 Q45F94 L0L8N9 K7ESB3 B2RCI5 |
| Accessions | AAZ38716 BAB18866 EAW60897 Q16853 AF054985 AAC09346 AF067406 AAC25170 AK025727 AK315129 BAG37582 BC036368 BC050549 AAH50549 DA592022 DB250074 JX020506 AGB67480 U39447 AAC50919 XM_011525419 XP_011523721 XM_011525420 XP_011523722 XR_934584 NM_001277731 NP_001264660 NM_001277732 NP_001264661 NM_003734 NP_003725 NR_102422 |
| Function | Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}. |
| Tissue Specificity | Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}. |
| Top Pathways | Glycine, serine and threonine metabolism, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism |
Human VAP-1 protein fragment - ab123541 from Abcam
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Human VAP1 full length protein - ab160132 from Abcam
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Human VAP1 protein fragment - ab160133 from Abcam
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Human VAP1 protein fragment - ab129129 from Abcam
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Rat VAP1 peptide - ab42883 from Abcam
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Rat VAP1 peptide - ab42884 from Abcam
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AOC3 / VAP-1 Antibody Blocking Peptide - LS-E26243 from LifeSpan Bioscience
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AOC3 / VAP-1 Antibody Blocking Peptide - LS-E9630 from LifeSpan Bioscience
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VAP-1/AOC3 Recombinant Protein - H00008639-P01 from Novus Biologicals
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Recombinant Human VAP-1/AOC3 Protein - H00008639-Q01 from Novus Biologicals
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AOC3-Antibody-Center-Blocking-Peptide - BP8538c from Abgent, a WuXi AppTec company
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VAP1 recombinant protein - GTX53863 from GeneTex
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VAP1 blocking peptide - GTX89161-PEP from GeneTex
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Recombinant Human VAP-1, CF - 3957-AO-010 from R&D Systems
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VAP1 Peptide - AC21-1075-P from Abcore
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Vap1 Peptide - AC21-2121-P from Abcore
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AOC3 / VAP1 - AR31003PU-N from Acris Antibodies
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AOC3 / VAP1 - AR31003PU-S from Acris Antibodies
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AOC3 / VAP1 - H00008639-P01 from Acris Antibodies
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AOC3 / VAP1 - H00008639-P01-25 from Acris Antibodies
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AOC3 / VAP1 - H00008639-Q01-10 from Acris Antibodies
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AOC3 / VAP1 - H00008639-Q01-25 from Acris Antibodies
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AOC3 / VAP1 - P6050 from Acris Antibodies
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VAP-1, Recombinant Human - 213-10457-1 from RayBiotech
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Recombinant Human VAP-1 - 213-10457-2 from RayBiotech
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