| Gene Symbol | AOC3 |
|---|---|
| Entrez Gene | 8639 |
| Alt Symbol | HPAO, SSAO, VAP-1, VAP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | amine oxidase, copper containing 3 |
| Other Description | amine oxidase, copper containing 3 (vascular adhesion protein 1)|copper amine oxidase|membrane primary amine oxidase|placenta copper monamine oxidase|semicarbazide-sensitive amine oxidase |
| Swissprots | Q16853 Q45F94 L0L8N9 K7ESB3 B2RCI5 |
| Accessions | AAZ38716 BAB18866 EAW60897 Q16853 AF054985 AAC09346 AF067406 AAC25170 AK025727 AK315129 BAG37582 BC036368 BC050549 AAH50549 DA592022 DB250074 JX020506 AGB67480 U39447 AAC50919 XM_011525419 XP_011523721 XM_011525420 XP_011523722 XR_934584 NM_001277731 NP_001264660 NM_001277732 NP_001264661 NM_003734 NP_003725 NR_102422 |
| Function | Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}. |
| Tissue Specificity | Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}. |
| Top Pathways | Glycine, serine and threonine metabolism, Phenylalanine metabolism, Tyrosine metabolism, beta-Alanine metabolism |
VAP-1 CRISPR/Cas9 KO Plasmid (h) - sc-401777 from Santa Cruz Biotechnology
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VAP-1 HDR Plasmid (h) - sc-401777-HDR from Santa Cruz Biotechnology
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VAP-1 Double Nickase Plasmid (h) - sc-401777-NIC from Santa Cruz Biotechnology
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VAP-1 Double Nickase Plasmid (h2) - sc-401777-NIC-2 from Santa Cruz Biotechnology
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VAP-1 CRISPR Activation Plasmid (h) - sc-401777-ACT from Santa Cruz Biotechnology
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VAP-1 CRISPR Activation Plasmid (h2) - sc-401777-ACT-2 from Santa Cruz Biotechnology
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VAP-1 Lentiviral Activation Particles (h) - sc-401777-LAC from Santa Cruz Biotechnology
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VAP-1 Lentiviral Activation Particles (h2) - sc-401777-LAC-2 from Santa Cruz Biotechnology
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VAP-1 siRNA (h) - sc-43197 from Santa Cruz Biotechnology
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VAP-1 shRNA Plasmid (h) - sc-43197-SH from Santa Cruz Biotechnology
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VAP-1 shRNA (h) Lentiviral Particles - sc-43197-V from Santa Cruz Biotechnology
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VAP-1/AOC3 RNAi - H00008639-R01 from Novus Biologicals
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MISSION® esiRNA - EHU043921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3275 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3275 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10268 from Sigma-Aldrich
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AOC3 siRNA (Human) - CRH5678 from Cohesion Biosciences
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AOC3 - MBS8220332 from MyBioSource
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VAP-1 CRISPR/Cas9 KO Plasmid (h2) - sc-401777-KO-2 from Santa Cruz Biotechnology
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VAP-1 HDR Plasmid (h2) - sc-401777-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human AOC3 (NM_003734.2) - SHH237670 from Creative biogene
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shRNA set against Human AOC3(NM_003734.2) - SHG061875 from Creative biogene
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AOC3 shRNA Plasmid (Human) - CHH5678 from Cohesion Biosciences
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AOC3 miRNA 3'UTR clone - MiUTR1H-00431 from Creative biogene
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