| Gene Symbol |
E2f6
|
| Entrez Gene |
50496
|
| Alt Symbol |
AI462434, E2F6b, EMA
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
E2F transcription factor 6
|
| Other Description |
E2F-6|E2F-binding site-modulating activity protein|transcription factor E2F6|transcriptional repressor E2F6
|
| Swissprots |
Q8K456 O54917
|
| Accessions |
AAL38216 AAL38217 AAM45941 AAM45942 EDK98479 O54917 AB221552 AF032131 AAC53521 AI851823 AK035116 BAC28950 AK075684 AK146792 BAE27435 AK149061 BAE28727 AK177128 AK183289 AK187122 BC019166 AAH19166 BC037656 AAH37656 BC057929 AAH57929 BY739130 CJ075693 XM_006515147 XP_006515210 XM_006515148 XP_006515211 XM_006515149 XP_006515212 XM_011243882 XP_011242184 NM_033270 NP_150373 NR_027677
|
| Function |
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|