Gene Symbol | E2f6 |
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Entrez Gene | 50496 |
Alt Symbol | AI462434, E2F6b, EMA |
Species | Mouse |
Gene Type | protein-coding |
Description | E2F transcription factor 6 |
Other Description | E2F-6|E2F-binding site-modulating activity protein|transcription factor E2F6|transcriptional repressor E2F6 |
Swissprots | Q8K456 O54917 |
Accessions | AAL38216 AAL38217 AAM45941 AAM45942 EDK98479 O54917 AB221552 AF032131 AAC53521 AI851823 AK035116 BAC28950 AK075684 AK146792 BAE27435 AK149061 BAE28727 AK177128 AK183289 AK187122 BC019166 AAH19166 BC037656 AAH37656 BC057929 AAH57929 BY739130 CJ075693 XM_006515147 XP_006515210 XM_006515148 XP_006515211 XM_006515149 XP_006515212 XM_011243882 XP_011242184 NM_033270 NP_150373 NR_027677 |
Function | Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
E2F-6 CRISPR/Cas9 KO Plasmid (m) - sc-424446 from Santa Cruz Biotechnology
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E2F-6 HDR Plasmid (m) - sc-424446-HDR from Santa Cruz Biotechnology
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E2F-6 Double Nickase Plasmid (m) - sc-424446-NIC from Santa Cruz Biotechnology
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E2F-6 Double Nickase Plasmid (m2) - sc-424446-NIC-2 from Santa Cruz Biotechnology
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E2F-6 CRISPR Activation Plasmid (m) - sc-424446-ACT from Santa Cruz Biotechnology
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E2F-6 CRISPR Activation Plasmid (m2) - sc-424446-ACT-2 from Santa Cruz Biotechnology
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E2F-6 Lentiviral Activation Particles (m) - sc-424446-LAC from Santa Cruz Biotechnology
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E2F-6 Lentiviral Activation Particles (m2) - sc-424446-LAC-2 from Santa Cruz Biotechnology
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E2F-6 siRNA (m) - sc-37820 from Santa Cruz Biotechnology
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E2F-6 shRNA Plasmid (m) - sc-37820-SH from Santa Cruz Biotechnology
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E2F-6 shRNA (m) Lentiviral Particles - sc-37820-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU053631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30369 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30369 from Sigma-Aldrich
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E2F6 siRNA (Mouse) - CRM5102 from Cohesion Biosciences
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E2F6 - MBS8207801 from MyBioSource
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shRNA set against Mouse E2F6 (NM_033270.2) - SHH282545 from Creative biogene
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Mouse E2F6 siRNA - orb284578 from Biorbyt
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E2F6 shRNA Plasmid (Mouse) - CHM5102 from Cohesion Biosciences
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