Gene Symbol | PI4KA |
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Entrez Gene | 5297 |
Alt Symbol | PI4K-ALPHA, PIK4CA, pi4K230 |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol 4-kinase, catalytic, alpha |
Other Description | PI4-kinase alpha|phosphatidylinositol 4-kinase 230|phosphatidylinositol 4-kinase alpha|phosphatidylinositol 4-kinase, type III, alpha|ptdIns-4-kinase alpha |
Swissprots | P42356 Q7Z625 Q9UPG2 |
Accessions | P42356 AB210002 BAE06084 AF012872 AAD13352 AK094594 AK095811 BAG53136 AK124692 AK131431 AK302424 BAG63727 AK314781 BAG37317 AL048955 BC018120 AAH18120 BC046202 BC053654 AAH53654 BC172398 AAI72398 BU685224 DA959365 L36151 AAA56839 XM_005261634 XP_005261691 XM_005261635 XP_005261692 XM_011530226 XP_011528528 XM_011530227 XP_011528529 XM_011530228 XP_011528530 XR_937868 NM_058004 NP_477352 NM_002650 |
Function | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. |
Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Associates with the membranes of Golgi vesicles and vacuoles. {ECO:0000250}. |
Tissue Specificity | Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. {ECO:0000269|PubMed:10101268, ECO:0000269|PubMed:7961848}. |
Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
PI 4-kinase α CRISPR/Cas9 KO Plasmid (h) - sc-406508 from Santa Cruz Biotechnology
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PI 4-kinase α HDR Plasmid (h) - sc-406508-HDR from Santa Cruz Biotechnology
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PI 4-kinase α Double Nickase Plasmid (h) - sc-406508-NIC from Santa Cruz Biotechnology
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PI 4-kinase α Double Nickase Plasmid (h2) - sc-406508-NIC-2 from Santa Cruz Biotechnology
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PI 4-kinase α CRISPR Activation Plasmid (h) - sc-406508-ACT from Santa Cruz Biotechnology
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PI 4-kinase α CRISPR Activation Plasmid (h2) - sc-406508-ACT-2 from Santa Cruz Biotechnology
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PI 4-kinase α Lentiviral Activation Particles (h) - sc-406508-LAC from Santa Cruz Biotechnology
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PI 4-kinase α Lentiviral Activation Particles (h2) - sc-406508-LAC-2 from Santa Cruz Biotechnology
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PI 4-kinase α siRNA (h) - sc-44012 from Santa Cruz Biotechnology
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PI 4-kinase α shRNA Plasmid (h) - sc-44012-SH from Santa Cruz Biotechnology
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PI 4-kinase α shRNA (h) Lentiviral Particles - sc-44012-V from Santa Cruz Biotechnology
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PIK4CA RNAi - H00005297-R03 from Novus Biologicals
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MISSION® esiRNA - EHU004121 from Sigma-Aldrich
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MISSION® siRNA - SIHK1631 from Sigma-Aldrich
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MISSION® siRNA - SIHK1635 from Sigma-Aldrich
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MISSION® siRNA - SIHK1636 from Sigma-Aldrich
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MISSION® siRNA - SIHK1632 from Sigma-Aldrich
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MISSION® siRNA - SIHK1633 from Sigma-Aldrich
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MISSION® siRNA - SIHK1634 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16769 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16769 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03208 from Sigma-Aldrich
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PI4KA siRNA (Human) - CRH3542 from Cohesion Biosciences
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PIK4CA RNAi - H00005297-R04 from Novus Biologicals
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PI 4-kinase α CRISPR/Cas9 KO Plasmid (h2) - sc-406508-KO-2 from Santa Cruz Biotechnology
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