ARHGEF7

Gene Symbol ARHGEF7
Entrez Gene 8874
Alt Symbol BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Species Human
Gene Type protein-coding
Description Rho guanine nucleotide exchange factor (GEF) 7
Other Description PAK-interacting exchange factor beta|SH3 domain-containing proline-rich protein|guanine nucleotide exchange factor 7|rho guanine nucleotide exchange factor 7
Swissprots Q86W63 Q3LIA4 Q8N3M1 Q6P9G3 Q6PII2 B1ALK8 Q14155 Q5W9H0 B1ALK6
Accessions EAX09142 EAX09143 EAX09144 EAX09145 EAX09146 EAX09147 EAX09148 EAX09149 Q14155 AA457036 AB075521 BAE45764 AB177848 BAD66826 AB177849 BAD66827 AJ844629 CAH59748 AJ844630 AJ844631 CAH59949 AJ844632 AJ844633 AK055476 AK093326 AK095058 AK295472 BAH12080 AK300157 BAH13225 AK300272 BAH13248 AK308897 AL834228 CAD38906 BC033905 AAH33905 BC050521 AAH50521 BC060776 AAH60776 BM677392 BX648314 CF121796 CF144155 D17055 D63476 BAA09763 DA216264 DB104833 DB180957 EU832475 ACE87647 EU832554 ACE86956 EU832819 ACE87830 GQ129214 ACT64348 XM_005254085 XP_005254142 XM_005254086 XP_005254143 XM_005254087 XP_005254144 XM_005254088 XP_005254145 XM_005254089 XP_005254146 XM_005254090 XP_005254147 XM_005254091 XP_005254148 XM_005254092 XP_005254149 XM_005254093 XP_005254150 XM_005254094 XP_005254151 XM_005254095 XP_005254152 XM_006719956 XP_006720019 XM_006719958 XP_006720021 XM_006719959 XP_006720022 XM_006719960 XP_006720023 XM_011521130 XP_011519432 XM_011521131 XP_011519433 XM_011521132 XP_011519434 XM_011521133 XP_011519435 NM_001113511 NP_001106983 NM_001113512 NP_001106984 NM_001113513 NP_001106985 NM_003899 NP_003890 NM_145735 NP_663788
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
Subcellular Location Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
Top Pathways Regulation of actin cytoskeleton

Cool1/βPix Antibody - 4515 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat, NIH/3T3, ZR-75, MCF-7 and COS cells using Cool1/βPix Antibody.

βPIX (C-19) - sc-10932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
βPIX (C-19): sc-10932. Western blot analysis of βPIX expression in Jurkat whole cell lysate.

βPIX (H-115) - sc-25418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

βPIX (L-17) - sc-10931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
βPIX (L-17): sc-10931. Western blot analysis of βPIX expression in non-transfected: sc-117752 (A) and human βPIX transfected: sc-177731 (B) 293T whole cell lysates.

Anti-ARHGEF7 antibody - ab175306 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ARHGEF7 antibody (ab175306) at 1/500 dilutionLane 1 : Jurkat cell lysateLane 2 : Cos-1 cell lysateLane 3 : Cos-7 cell lysateLane 4 : MCF-7 cell lysateLane 5 : K562 cell lysateLane 6 : Lung lysateLane 7 : Heart lysate

Anti-ARHGEF7 antibody - ab92657 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ARHGEF7 antibody (ab92657) at 1/500 dilutionLane 1 : Rat heart lysate Lane 2 : Rat muscle lysate Lane 3 : Rat heart lysate with blocking peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-ARHGEF7 antibody - ab170255 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ARHGEF7 antibody (ab170255) at 1/1000 dilution + HepG2 cell lysate

Anti-ARHGEF7 antibody - ab125870 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ARHGEF7 antibody (ab125870) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

Anti-ARHGEF7 antibody - C-terminal - ab195656 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ARHGEF7 antibody - C-terminal (ab195656) at 1/500 dilution + MDA cell lysate

Anti-ARHGEF7 Antibody (Gln344) - LS-C192132 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF7 Antibody - LS-C309506 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF7 Antibody (HRP) - LS-C317005 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF7 Antibody (Biotin) - LS-C317006 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF7 Antibody (FITC) - LS-C317007 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARHGEF7 Antibody (aa311-360) - LS-C120334 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from rat muscle/rat heart cells, using ARHGEF7 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ARHGEF7 Antibody (Biotin) - LS-C344804 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis using anti-beta-Pix (mouse), pAb (Biotin) . 1: Mouse brain lysates (30 ug). 2: NIH3T3 whole cell lysates (30 ug). . * beta-Pix is a major isoform in NIH3T3 lysates, while other beta-Pix isoforms are also detected in mouse brain lysates.

Anti-ARHGEF7 Antibody - LS-C344954 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis using anti-beta-Pix (mouse), pAb . 1: Mouse brain lysates (30 ug). 2: NIH3T3 whole cell lysates (30 ug). . * beta-Pix is a major isoform in NIH3T3 lysates, while other beta-Pix isoforms are also detected in mouse brain lysates.

Anti-ARHGEF7 Antibody - LS-C331262 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using ARHGEF7 antibody.

Anti-ARHGEF7 Antibody - LS-C192374 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ARHGEF7 pAb in extracts from Jurkat, COS1, COS7, MCF7, K562 cells and mouse lung, heart tissues.

Anti-ARHGEF7 Antibody IHC-plus™ - LS-B12261 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

NFkB p105/p50 Antibody (5D10D11) - NBP2-22178 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D10D11
Western Blot: NFkB p105/p50 Antibody (5D10D11) [NBP2-22178] - Western blot analysis using NFkB p105/p50 mouse mAb against K562 (1), Jurkat (2), A431 (3), Hela (4), THP-1 (5) and MCF-7 (6) cell lysate.

NFkB p105/p50 Antibody (5D10) - NBP2-22202 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D10
Western Blot: NFkB p105/p50 Antibody (5D10) [NBP2-22202] - Western blot analysis using NFkB p105/p50 mouse mAb against K562 (1), Jurkat (2), A431 (3), Hela (4), THP-1 (5) and MCF-7 (6) cell lysate.

ARHGEF7 Antibody - NBP1-88650 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ARHGEF7 Antibody [NBP1-88650] - Analysis in human cell line SH-SY5Y.

ARHGEF7 Antibody - NBP2-15458 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ARHGEF7 Antibody - H00008874-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: ARHGEF7 Antibody [H00008874-A01] - ARHGEF7 polyclonal antibody (A01), Lot # 051128JC01 Western Blot analysis of ARHGEF7 expression in U-2 OS ( Cat # L022V1 ).
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