ARHGEF7
| Gene Symbol | ARHGEF7 |
|---|---|
| Entrez Gene | 8874 |
| Alt Symbol | BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho guanine nucleotide exchange factor (GEF) 7 |
| Other Description | PAK-interacting exchange factor beta|SH3 domain-containing proline-rich protein|guanine nucleotide exchange factor 7|rho guanine nucleotide exchange factor 7 |
| Swissprots | Q86W63 Q3LIA4 Q8N3M1 Q6P9G3 Q6PII2 B1ALK8 Q14155 Q5W9H0 B1ALK6 |
| Accessions | EAX09142 EAX09143 EAX09144 EAX09145 EAX09146 EAX09147 EAX09148 EAX09149 Q14155 AA457036 AB075521 BAE45764 AB177848 BAD66826 AB177849 BAD66827 AJ844629 CAH59748 AJ844630 AJ844631 CAH59949 AJ844632 AJ844633 AK055476 AK093326 AK095058 AK295472 BAH12080 AK300157 BAH13225 AK300272 BAH13248 AK308897 AL834228 CAD38906 BC033905 AAH33905 BC050521 AAH50521 BC060776 AAH60776 BM677392 BX648314 CF121796 CF144155 D17055 D63476 BAA09763 DA216264 DB104833 DB180957 EU832475 ACE87647 EU832554 ACE86956 EU832819 ACE87830 GQ129214 ACT64348 XM_005254085 XP_005254142 XM_005254086 XP_005254143 XM_005254087 XP_005254144 XM_005254088 XP_005254145 XM_005254089 XP_005254146 XM_005254090 XP_005254147 XM_005254091 XP_005254148 XM_005254092 XP_005254149 XM_005254093 XP_005254150 XM_005254094 XP_005254151 XM_005254095 XP_005254152 XM_006719956 XP_006720019 XM_006719958 XP_006720021 XM_006719959 XP_006720022 XM_006719960 XP_006720023 XM_011521130 XP_011519432 XM_011521131 XP_011519433 XM_011521132 XP_011519434 XM_011521133 XP_011519435 NM_001113511 NP_001106983 NM_001113512 NP_001106984 NM_001113513 NP_001106985 NM_003899 NP_003890 NM_145735 NP_663788 |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}. |
| Subcellular Location | Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions. |
| Top Pathways | Regulation of actin cytoskeleton |
βPIX siRNA (h) - sc-39148 from Santa Cruz Biotechnology
|
||||||||
βPIX shRNA Plasmid (h) - sc-39148-SH from Santa Cruz Biotechnology
|
||||||||
βPIX shRNA (h) Lentiviral Particles - sc-39148-V from Santa Cruz Biotechnology
|
||||||||
ARHGEF7 RNAi - H00008874-R01 from Novus Biologicals
|
||||||||
ARHGEF7 RNAi - H00008874-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU094361 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3463 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3463 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR11586 from Sigma-Aldrich
|
||||||||
ARHGEF7 siRNA (Human) - CRH5861 from Cohesion Biosciences
|
||||||||
ARHGEF7 - MBS8230772 from MyBioSource
|
||||||||
shRNA set against Human ARHGEF7 (NM_003899.3) - SHH239902 from Creative biogene
|
||||||||
shRNA set against Human ARHGEF7(NM_003899.3) - SHG071335 from Creative biogene
|
||||||||
shRNA set against Human ARHGEF7(NM_145735.2) - SHG071377 from Creative biogene
|
||||||||
Human ARHGEF7 siRNA - orb266363 from Biorbyt
|
||||||||
ARHGEF7 shRNA Plasmid (Human) - CHH5861 from Cohesion Biosciences
|
||||||||
ARHGEF7 miRNA 3'UTR clone - MiUTR1H-00547 from Creative biogene
|
||||||||
ARHGEF7 miRNA 3'UTR clone - MiUTR1H-00548 from Creative biogene
|
||||||||
ARHGEF7 miRNA 3'UTR clone - MiUTR4H-TG00473 from Creative biogene
|