ARHGEF7

Gene Symbol	ARHGEF7
Entrez Gene	8874
Alt Symbol	BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Species	Human
Gene Type	protein-coding
Description	Rho guanine nucleotide exchange factor (GEF) 7
Other Description	PAK-interacting exchange factor beta|SH3 domain-containing proline-rich protein|guanine nucleotide exchange factor 7|rho guanine nucleotide exchange factor 7
Swissprots	Q86W63 Q3LIA4 Q8N3M1 Q6P9G3 Q6PII2 B1ALK8 Q14155 Q5W9H0 B1ALK6
Accessions	EAX09142 EAX09143 EAX09144 EAX09145 EAX09146 EAX09147 EAX09148 EAX09149 Q14155 AA457036 AB075521 BAE45764 AB177848 BAD66826 AB177849 BAD66827 AJ844629 CAH59748 AJ844630 AJ844631 CAH59949 AJ844632 AJ844633 AK055476 AK093326 AK095058 AK295472 BAH12080 AK300157 BAH13225 AK300272 BAH13248 AK308897 AL834228 CAD38906 BC033905 AAH33905 BC050521 AAH50521 BC060776 AAH60776 BM677392 BX648314 CF121796 CF144155 D17055 D63476 BAA09763 DA216264 DB104833 DB180957 EU832475 ACE87647 EU832554 ACE86956 EU832819 ACE87830 GQ129214 ACT64348 XM_005254085 XP_005254142 XM_005254086 XP_005254143 XM_005254087 XP_005254144 XM_005254088 XP_005254145 XM_005254089 XP_005254146 XM_005254090 XP_005254147 XM_005254091 XP_005254148 XM_005254092 XP_005254149 XM_005254093 XP_005254150 XM_005254094 XP_005254151 XM_005254095 XP_005254152 XM_006719956 XP_006720019 XM_006719958 XP_006720021 XM_006719959 XP_006720022 XM_006719960 XP_006720023 XM_011521130 XP_011519432 XM_011521131 XP_011519433 XM_011521132 XP_011519434 XM_011521133 XP_011519435 NM_001113511 NP_001106983 NM_001113512 NP_001106984 NM_001113513 NP_001106985 NM_003899 NP_003890 NM_145735 NP_663788
Function	Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
Subcellular Location	Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
Top Pathways	Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ARHGEF7 protein (His-DHFR tag) - ab127465 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human ARHGEF7 Protein - H00008874-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ARHG7-Antibody-C-term-Blocking-peptide - BP12266b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARHG7-Antibody-N-term-Blocking-Peptide - BP7992a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Rho guanine nucleotide exchange factor 7 (OPCA00394) - OPCA00394 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human ARHGEF7 protein - orb246672 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human ARHGEF7 protein - orb246673 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

NF-kappaB p105/p50 (phospho-Ser337) Blocking Peptide - abx062994 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Dog, Pig

NF-kappaB p105/p50 Blocking Peptide - abx062995 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Dog, Pig

ARHGEF7 - H00008874-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ARHGEF7 - H00008874-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ARHGEF7 fusion protein - Ag5223 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

ARHGEF7 fusion protein - ag5344 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ARHGEF7, GST-tagged - ARHGEF7-9840H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Rho Guanine Nucleotide Exchange Factor 7 (ARHGEF7) - RPJ851Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

ARHGEF7 (Q344) Peptide - BS3929P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant human Rho guanine nucleotide exchange factor 7 - CSB-EP014454h(C) CSB-BP014454h(C) CSB-MP014454h(C) from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Rho guanine nucleotide exchange factor 7 - CSB-EP014454h CSB-BP014454h CSB-MP014454h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Rho guanine nucleotide exchange factor 7(ARHGEF7) ,partial - CSB-RP014454h(C) from Cusabio Category Protein Source E.coli Species Human

Recombinant human Rho guanine nucleotide exchange factor 7 - CSB-RP014454h from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Rho guanine nucleotide exchange factor 7(ARHGEF7) ,partial - CSB-YP618876HU CSB-EP618876HU CSB-BP618876HU CSB-MP618876HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NF-kB p105/p50(Phospho-Ser893) antibody blocking peptide - 51018 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

NF-kB p105/p50(Phospho-Ser907) antibody blocking peptide - 51019 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

Rho guanine nucleotide exchange factor 7 - RPC141128 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Rho guanine nucleotide exchange factor 7 - RPC141129 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

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