| Gene Symbol |
EIF4G2
|
| Entrez Gene |
1982
|
| Alt Symbol |
AAG1, DAP5, NAT1, P97
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 4 gamma, 2
|
| Other Description |
DAP-5|aging-associated protein 1|death-associated protein 5|eIF-4-gamma 2|eIF-4G 2|eIF4G 2|eukaryotic translation initiation factor 4 gamma 2|eukaryotic translation initiation factor 4G-like 1
|
| Swissprots |
Q58EZ2 Q49A79 Q2NKW9 Q0VH01 P78344 Q0VH00 O60877 Q8NI71 Q53EU1 Q96C16 P78404
|
| Accessions |
EAW68552 EAW68553 EAW68554 EAW68555 P78344 AB063323 BAB93515 AB073654 BAE45728 AB209267 BAD92504 AI362365 AK123338 AK223548 BAD97268 AK302886 BAG64064 AK310387 AK310738 AY513274 AAT08027 BC014930 AAH14930 BC018746 AAH18746 BC018975 AAH18975 BC039851 AAH39851 BC043149 AAH43149 BC065276 AAH65276 BC111415 AAI11416 BC111548 AAI11549 BX647799 DB072494 DB231980 DB272352 U73824 AAB49973 U76111 AAC51166 X89713 CAA61857 NM_001042559 NP_001036024 NM_001172705 NP_001166176 NM_001418 NP_001409
|
| Function |
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.
|
| Tissue Specificity |
Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney. {ECO:0000269|PubMed:9030685, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.
|
| Top Pathways |
RNA transport
|