| Gene Symbol |
HEXIM2
|
| Entrez Gene |
124790
|
| Alt Symbol |
L3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hexamethylene bis-acetamide inducible 2
|
| Other Description |
MAQ1 paralog|hexamethylene bis-acetamide-inducible protein 2|hexamethylene-bis-acetamide-inducible transcript 2|protein HEXIM2
|
| Swissprots |
D3DX66 Q96MH2
|
| Accessions |
EAW51541 EAW51542 Q96MH2 AA223138 AK056946 BAB71319 AK096785 AW340131 AY598322 AAT06733 BC003531 AAH03531 BC012474 AAH12474 BC025970 AAH25970 BG696988 BI829228 BI829844 BP209696 BP398345 BU501076 CA312679 CN425800 DB160394 HQ447675 ADQ32160 HY007091 XM_006721687 XP_006721750 XM_011524302 XP_011522604 XM_011524303 XP_011522605 XM_011524304 XP_011522606 XM_011524305 XP_011522607 XM_011524306 XP_011522608 XM_011524307 XP_011522609 XM_011524308 XP_011522610 NM_001303436 NP_001290365 NM_001303437 NP_001290366 NM_001303438 NP_001290367 NM_001303439 NP_001290368 NM_001303440 NP_001290369 NM_001303441 NP_001290370 NM_001303442 NP_001290371 NM_001303443 NP_001290372 NM_001303444 NP_001290373 NM_144608 NP_653209
|
| Function |
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15994294}.
|
| Tissue Specificity |
Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed. {ECO:0000269|PubMed:15713661}.
|
![Western Blot: HEXIM2 Overexpression Lysate (Adult Normal) [NBP2-04423] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HEXIM2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8098_HEXIM2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04423-img0001.jpg)